Mitochondrial Retrograde Signalling in Plants – New Models and Analytical Approaches

线粒体是植物细胞中参与能量生产和各种代谢和生物合成途径的重要细胞器。来自线粒体的信号调节核基因表达，以协调线粒体活性与细胞活性，这被称为线粒体逆行信号（MRS）。到目前为止，我们的知识的途径和成分参与MRS是有限的，以一个单一的模型系统。该提案旨在确定额外的MRS途径，这些途径的MRS组分和所涉及的信号。这一新知识可以用于转化研究，作为培育具有改变的胁迫和生长特性的植物的基础。

Mitochondria are essential organelles involved in energy production and various metabolic and biosynthetic pathways in plant cells. Signals from mitochondria act to regulate nuclear gene expression to coordinate mitochondrial activity with cellular activity, which is called mitochondrial retrograde signalling (MRS). To date our knowledge of the pathways and components involved in MRS is limited to a single model system. This proposal seeks to identify additional MRS pathways, characterise components of these pathways and the signals involved. This new knowledge can be used in translational research as a basis to breed plants with altered stress and growth properties.