Attention Disorders Assessed By Event Related Brain Pote

我们已经在《生物心理学》上发表了一篇关于认知ERP(事件相关脑电位)成分的季节性影响的报告(Kosmidis等人，1999)。目前正在准备的是关于可乐定(一种去甲肾上腺素阻滞剂)对正常受试者ERPs的影响的报道，以及正常对照组和两组癫痫患者之间的比较。后者的研究表明，颞叶癫痫患者的事件相关电位在大多数方面与正常对照组相似；相比之下，失神癫痫患者的事件相关电位显示认知成分的幅度降低，特别是P300和慢波。这些差异主要体现在听觉信号的处理上。我们希望与健康科学统一服务大学的同事们一起重新启动这一项目。《心理生理学》杂志发表了一篇手稿，描述了闭合性头部损伤对注意力要求高的任务中ERPs的影响。研究结果表明，在这些患者中，与刺激识别和分类有关的N200成分的变化，特别是在听觉通道中发生了变化。这些可能是信息处理方面的永久性变化，因为患者平均在受伤后七年。邓肯博士是一名客座研究员，我和他还提议对这一一般性领域进行一次综述，该综述将发表在《国际心理生理学杂志》上。这篇评论已经被接受出版，并将于今年出版。

We have published in Biological Psychology a report of seasonal effects on the amplitude of cognitive ERP (Event-Related brain Potentials) components (Kosmidis et al., 1999). In preparation at this time are reports of the effects of clonidine (a norepinephrine blocker) on ERPs in normal subjects, as well as a comparison among normal controls and two groups of patients with seizure disorders. The latter study indicated that ERPs in patients with temporal lobe seizures resemble in most respects those seen in normal control subjects; in contrast, ERPs in patients with absence epilepsy show reduced amplitudes of cognitive components, especially P300 and slow wave. The differences were seen primarily in the processing of auditory signals. We are hoping to reactivate this project, in conjunction with colleagues at the Uniformed Services University of the Health Sciences. A manuscript describing the effects of closed head injuries on ERPs in attention-demanding tasks has been published by the journal Psychophysiology. The findings indicate that changes in the N200 component, concerned with identification and classification of stimuli, is altered in these patients, particularly in the auditory modality. These are presumably permanent changes in information processing, as the patients were on the average seven years post-injury. Dr. Duncan, a Guest Researcher, and I have also proposed a review of this general area, which is to appear in the International Journal of Psychophysiology. This review has been accepted for publication and will appear this year.