Communicore Animal Facility (CAF) Renovation Phase III Part II

描述(由申请人提供)： 2001年，佛罗里达大学启动了一项十年计划，以改进、扩大和集中其动物资源计划，以提供尽可能好的环境进行科学研究，为实验室动物提供优质护理，以及安全的工作环境，同时确保符合动物福利法和指南。该提案描述了一个三阶段计划，以实现现有最大的动物设施--社区动物设施(CAF)的现代化，并进一步集中动物资源计划。第一阶段更换了CAF陈旧的供暖、通风和空调(HVAC)供应单元，但不能解决该系统的分布和控制缺陷。第二阶段正在规划阶段，将在CAF的基础上增加62,000平方英尺(GSF)，作为紧邻CAF的172,000 GSF生物医学大楼的一部分。第三阶段根据现有暖通空调系统提供的AEA分为三个部分。第三阶段将更换破旧的暖通空调，并重新配置CAF。第一部分的计划将扩大和现代化的CAF ABSL3套房正在进行中。第三部分将翻新CAF的东半部分，并将最后完成。 这项提议是第三阶段的第二部分，将用现代完全冗余的暖通空调系统取代旧的暖通空调系统，该系统服务于CAF约22,750 GSF，具有数字控制和监测，使用自动调节的压力独立阀门。此外，中央手术中心将重新配置，提供一个禁区，提供一个预备室和专门为有生物危害的动物进行的手术。检疫区将重新配置，为可能具有传染性的笼子和材料及其有效的净化提供出口。此外，通过提供一种新的入口和方法来高效地对进入的笼子和材料进行消毒，将缩短从新的CAF附件笼子洗涤器进入ABSL3的无菌笼子的路线。所有大型动物室、外科套房、动物预备室以及检疫和ABSL3入口都将采用气相过氧化氢灭菌。动物室和手术室的电气服务将得到升级。我们建议为这个项目提供部分资金，NIH要求每1美元，大学就提供5.12美元。

DESCRIPTION (provided by applicant): In 2001 The University of Florida initiated a 10 year plan to improve, enlarge and centralize its animal resource program to provide the best possible environment for scientific inquiry, quality care to laboratory animals, and a safe work environment while ensuring conformity with the Animal Welfare Act and the Guide. This proposal describes a three-phase plan to modernize the largest existing animal facility, the Communicore Animal Facility (CAF), and further centralize the animal resource program. Phase I replaced the worn out (>30yr old) heating, ventilation, and air conditioning (HVAC) supply units of CAF but could not address the distribution and control deficiencies of the system. Phase II is in the planning stage and will construct a 62,000 gross square feet (gsf) addition to CAF as part of a 172,000 gsf Biomedical Sciences Building immediately adjacent to CAF. Phase III has three parts based on the aea served by the existing HVAC system. Phase III will replace the remainder of the worn out HVAC and reconfigure CAF. Planning for Part I which will enlarge and modernize the CAF ABSL3 suite is underway. Part 3 will renovate the east half of CAF and will be done last. This proposal is Part 2 of Phase III and will replace the portion of the worn out HVAC system that serves about 22,750 gsf of the CAF with a modern fully redundant HVAC system with digital controls and monitoring, utilizing self regulating pressure independent valves. In addition, the central surgery will be reconfigured to provide a restricted area with a prep room and surgery dedicated for animals with biohazards. The quarantine area will be reconfigured to provide an exit for potentially infectious caging and materials and their efficient decontamination. Additionally, the route of sterile caging into the ABSL3 from the new CAF Annex cage wash will be shortened by providing a new entrance and method for sterilizing incoming caging and material in an efficient manner. All large animal rooms, surgical suites, animal prep rooms and the quarantine and ABSL3 entrances will be constructed to utilize vapor phase hydrogen peroxide sterilization. Electrical service in animal rooms and the surgical suite will be upgraded. We propose partial funding of this project with the University providing $5.12 for each $1.00 requested from NIH.