Development and Improvement of an Animal Resource Core

描述（由申请人提供）： 动物园在公共卫生方面的相关性是提供服务和资源，以帮助和支持动物模型的开发和维护，用于推进与年龄相关的疾病和衰老机制的研究。动物园的设计将包括维持现有的和发展中的转基因品系，由合作机构内部和外部使用，并向调查人员提供具体服务。具体而言，动物园将提供实验动物护理评估和认可协会（AAALAC）认证的设施，超过所有州和联邦法规，以维持与以下相关的动物模型：基因表达随年龄的变化、与有丝分裂和有丝分裂后组织相关的退行性疾病模型、死亡动力学和实验药物治疗以及各种转基因小鼠模型。动物饲养室和这些动物模型将结合联合收割机的专业知识，研究人员，技术人员和设施管理，以促进跨学科的方法来细胞调控，分化，增殖，转化和转移。动物园将为无特定病原体和免疫缺陷动物提供饲养护理和兽医护理，以及以下服务：技术应用（注射、给药）、手术应用（包括用于诱导特定转基因品系的微量注射）、卵巢移植手术、繁殖群体维持、安乐死培训和服务、灌注、尸检服务、常规血清学监测和测试，检疫程序和针对方案特定需求的工作人员培训，并将确保动物使用者所需的培训政策。需要额外的通风笼舍设备，以便于圈养当前研究和转基因生产服务中生产的额外动物。通风设备将降低饲养和垫料供应成本。需要转基因和技术服务设备来支持每年大约40个新构建体和利用动物饲养场的当前研究，这些研究预计在明年内进行菌落扩增。主治兽医将为提交给机构动物护理和使用委员会（IACUC）的所有手术和技术建议提供专家建议和指导，并将通过动物园健康监测计划解决群体中的健康问题。

DESCRIPTION (provided by applicant): The relevance of the vivarium in regard to public health is to provide the services and resources to assist and support the development and maintenance of animal models used to advance the study of age-related diseases and mechanisms of aging. The vivarium design will be comprised of maintaining current and developing transgenic lines, utilized both internally and externally by collaborating institutions, and of specific services offered to the investigative staff. Specifically, the vivarium will provide an Association for the Assessment and Accreditation of Laboratory Animal Care (AAALAC) accredited facility, exceeding all state and federal regulations, to maintain animal models relating to: changes in gene expression with age, degenerative disease models pertaining to mitotic and post-mitotic tissues, mortality kinetics and experimental drug therapies in conjunction with a variety of transgenic mouse models. The vivarium and these animal models will combine the expertise of investigative staff, technical staff and facility management to facilitate interdisciplinary approaches to cell regulation, differentiation, proliferation, transformation and metastasis. The vivarium will provide husbandry care, and veterinary care of specific-pathogen free and immunodeficient animals, as well as the following services: technical applications (injections, dosing), surgical applications to include micro-injections for induction of specific transgenic lines, ovarian transfer surgeries, breeding colony maintenance, euthanasia training and services, perfusions, necropsy services, routine serology monitoring and testing, quarantine procedures, and staff training for protocol specific needs and will ensure required training policies for animal users. Additional ventilated caging equipment is requested to facilitate housing the additional animals produced on current studies and from the transgenic production services. The ventilated equipment will reduce the husbandry and bedding supply costs. The transgenic and technical service equipment is needed to support approximately 40 new constructs per year and current studies utilizing the vivarium that have anticipated colony expansion within the next year. The Attending Veterinarian will provide expert advice and guidance for all surgical and technical proposals that are submitted to the Institutional Animal Care and Use Committee (IACUC), and will address health issues in the colonies via the vivarium health surveillance program.