APPLICATION OF CELLULAR KINETICS AND MOLECULAR DYNAMICS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 博士药理学教授Donnell Bowen在本项目期间作为试点项目研究者获得资助。 他的项目被命名为 细胞动力学和分子动力学在区分乳腺癌和正常细胞中无毒5-氟尿嘧啶剂量、还原叶酸、甲氨蝶呤和Alimta的选择性中的应用. 该项目已资助4年。 五年十月十七日，伯温大夫因病重去世。 在外部和内部咨询委员会的指导下，批准使用Bowen博士剩余的最后一年支持的项目，为4个不同的项目提供有竞争力的种子资金支持。 这些项目及其收到的资金如下。 每个项目的进展情况见分项目一节。 1. 博士Indira Poola，生物化学和分子生物学，预测浸润性乳腺癌发展的分子标记物的回顾性验证，24，720美元。 2. 博士乔治·哈达德，核因子κ B在心脏肥大进展为心力衰竭中的作用，生理学和生物物理学，24，720美元。 3. 博士Sergei Nekhai，蛋白磷酸酶-1作为抗HIV-1逆转录病毒治疗的新靶点，镰状细胞病中心，24，720美元。 4. 博士罗伯特·L·科普兰，合成和评价亚氨基取代萘醌衍生物作为Ras-MAPK信号级联激酶抑制剂，药理学，24，720美元。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Dr. Donnell Bowen, Professor of Pharmacology received funding in the current project period as a pilot project investigator. His project was entitled Application of Cellular Kinetics and Molecular Dynamics in Distinguishing Selectivity among a Non-Toxic 5-Fluorouracil Dose, Reduced Folates, Methotrexate, and Alimta in Breast Cancer and Normal Cells. This project was funded for 4 years. On October 17, 2005, Dr. Bowen died as a result of a serious illness. With guidance from both the External and Internal Advisory committees, approval was granted to utilize the final year of support remaining on Dr. Bowens project to provide competitive seed-money support for 4 different projects. These projects and the funds they received are listed below. The progress made on each project is presented in the subprojects section. 1. Dr. Indira Poola, Biochemistry and Molecular Biology, Retrospective Validation of Molecular markers for predicting development of Invasive Breast Cancer, $24,720. 2. Dr. Georges Haddad, Role of Nuclear Factor Kappa-B in the progression of Cardiac Hypertrophy into heart failure, Physiology and Biophysics, $24,720. 3. Dr. Sergei Nekhai, Protein Phosphatase-1 as a New Target for Anti-HIV-1 Retroviral Therapeutics, Center for Sickle Cell Disease, $24,720. 4. Dr. Robert L.Copland, Synthesis and evaluation of imido-substituted-naphthoquinone derivatives as inhibitor of kinases of the Ras-MAPK signaling cascade, Pharmacology, $24,720.