Center for Hemoglobin Research in Minorities (CHaRM)

少数民族血红蛋白研究中心 (CHaRM)

• 批准号: 9320021
• 负责人: SERGEI NEKHAI
• 金额: $ 142.82万
• 依托单位: HOWARD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-22 至 2020-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9320021
• 关键词: Acquired Immunodeficiency Syndrome; Administrator; African American; Anemia; Antimalarials; Award; Behavioral Research; Biomedical Research; Cancer Grant Supplements (P30); Chronic Disease; Clinical; Clinical Sciences; Collaborations; Communicable Diseases; Core Facility; Decision Making; Development; Direct Costs; District of Columbia; Doctor of Philosophy; Educational Curriculum; Educational workshop; Faculty; Funding; Goals; Grant; HIV-1; Heart Diseases; Hematological Disease; Hemoglobin; Hemoglobinopathies; Historically Black Colleges and Universities; Human Resources; Hypoxia; Interview; Iron; Lung diseases; Manuscripts; Medical; Medical Students; Mentorship; Minority; Minority-Serving Institution; Mission; Molecular; National Heart, Lung, and Blood Institute; Oxygen; Peer Review; Phase; Pilot Projects; Population; Positioning Attribute; Principal Investigator; Process; Proteomics; Public Health; Publishing; Recruitment Activity; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Scientist Award; Research Support; Research Training; Resources; Scientist; Sickle Cell Anemia; Source; Students; Training; Training Activity; Training and Education; Translational Research; United States National Institutes of Health; Universities; Update; Vulnerable Populations; Wages; Writing; career development; faculty research; faculty support; falls; follow-up; graduate student; health disparity; high school; improved; interest; iron metabolism; laboratory experience; lecturer; lectures; member; minority student; novel; programs; ranpirnase; repository; research and development; response; science education; success; undergraduate student

DESCRIPTION (provided by applicant): We propose to establish the Center for Hemoglobin Research in Minorities (CHaRM), which will build on and synergize with the existing HBCU Research Scientist Program. The CHaRM's ultimate goal is to provide and to improve the necessary research infrastructure, while augmenting science education and research training for pre- and postdoctoral students, and strengthening scientific faculty research and career development. We will establish a NHLBI Research Center at Howard University that will augment and strengthen research capabilities and resources in biomedical and behavioral research related to heart, lung and blood diseases and disorders in minority populations. This proposal will build on previously developed Research Scientist Program at Howard University's Center for Sickle Cell Disease (CSCD) that was supported by NHLBI from 1999 to 2012 and recently received the P30 award for Phase I of this program. In Aim 1, we will establish a center of excellence for the study of hemoglobinopathies, iron metabolism, and oxygen sensing. We will recruit an external mid-level or senior investigator who will serve as program director and retain the existing recently hired junior faculty. We will also establish a steering committee, an external advisory board and use an external evaluator for the program. In Aim 2, we will establish an administrative core to provide support and conduct training activities. In Aim 3, we will educate and train minority students and fellows by providing research and laboratory experience, developing additional scientific curricula, facilitate scientific exchange and conduct seminars. In Aim 4, we will expand and enhance the research advances made by the Howard University Research Scientist Program in clinical and molecular aspects of sickle cell disease, iron metabolism, and oxygen sensing. In Aim 5, we will enhance and facilitate existing collaborations within and outside of Howard University and share existing resources. The underlying themes of the research we envision are to reduce health disparities and to enhance excellence in research into heart, lung and blood diseases at Howard University. In pursuit of the scientific and educational goals, an integral part of the program will be to obtain additional research support from NIH and other sources. RELEVANCE: The mission of the CHaRM is relevant to public Health because it is aimed at reducing health disparities and enhancing excellence into heart, lung and blood diseases at Howard University. The proposed activities are relevant to the NIH mission that pertains to reduce vulnerability of the population to chronic and infectious diseases and to train and educate minority students and medical fellows.

描述（由申请人提供）：我们建议建立少数民族血红蛋白研究中心（CHaRM），该中心将建立在现有HBCU研究科学家计划的基础上并与之协同作用。CHaRM的最终目标是提供和改善必要的研究基础设施，同时加强科学教育和研究前和博士后学生的培训，并加强科研人员的研究和职业发展。我们将在霍华德大学建立一个NHLBI研究中心，该中心将扩大和加强与少数民族心脏、肺和血液疾病和障碍有关的生物医学和行为研究的研究能力和资源。该提案将建立在霍华德大学镰状细胞病中心（CSCD）先前开发的研究科学家计划的基础上，该计划于1999年至2012年得到NHLBI的支持，最近获得了该计划I期的P30奖。在目标1中，我们将建立一个卓越的血红蛋白病，铁代谢和氧传感研究中心。我们将招聘一名外部中级或高级调查员，他将担任项目主任，并保留现有的新聘用的初级教师。我们还将建立一个指导委员会、一个外部咨询委员会，并为该计划聘请一名外部评估员。在目标2方面，我们会设立一个行政核心，提供支援和举办培训活动。在目标3中，我们将通过提供研究和实验室经验、开发更多的科学课程、促进科学交流和举办研讨会，教育和培训少数民族学生和研究员。在目标4中，我们将扩大和加强霍华德大学研究科学家计划在镰状细胞病，铁代谢和氧传感的临床和分子方面的研究进展。在目标5中，我们将加强和促进霍华德大学内外的现有合作，并共享现有资源。我们设想的研究的基本主题是减少健康差距，提高霍华德大学心脏、肺和血液疾病研究的卓越性。为了实现科学和教育目标，该计划的一个组成部分将是从NIH和其他来源获得额外的研究支持。 相关性：CHaRM的使命与公共卫生有关，因为它旨在减少健康差距，并在霍华德大学提高对心脏，肺和血液疾病的卓越性。拟议的活动与国家卫生研究所的使命有关，该使命涉及减少人口对慢性病和传染病的脆弱性，以及培训和教育少数民族学生和医学研究员。