Melanoma Margins Trial-II: A Phase III, Multi-centre Randomised Controlled Trial Investigating 1cm vs 2cm Wide Surgical Excision Margins for AJCC Stage II Primary Cutaneous Melanoma (MelMarT-II)

原发性黑色素瘤（PM）通常以宽边缘切除以防止复发。对于具有较高风险PM的患者，关于切除边缘的范围存在争议。我们建议，对于高风险PM患者，1cm边界将实现与推荐的2cm边界相同的生存结局，同时提高生活质量并降低社区成本。这项试验将使世界各地的患者受益，影响护理，临床实践和未来的治疗指南。

Primary melanomas (PM) are routinely excised with a wide margin to prevent recurrence. For patients with higher risk PM, there is debate as to the extent of the excision margin. We propose a 1cm margin will achieve equivalent survival outcomes to the recommended 2cm margin for patients with higher risk PM, while improving quality of life and reducing costs to the community. This trial will benefit patients worldwide, influencing care, clinical practice and future treatment guidelines.