Daily Memory Lapses and Sympathetic-Cardiovascular Dysfunction: Pathways to Prevention of Alzheimer's Disease and Related Dementias (ADRD)

项目总结 目前的项目将研究对日常记忆丧失的负面情绪反应是否以及如何 与年轻健康成年人的交感-心血管功能障碍有关。每天的记忆力衰退是一种 在一些成年人中，无论年龄大小，常见的日常经历都会导致情绪困扰。我们的 以前的研究表明，这种情绪困扰在年轻人中会加剧，甚至会持续下去 在考虑了其他类型的日常压力经历(例如，争吵或工作压力源)之后。考虑到 应激源引起的情绪困扰与许多生理、情绪和认知因素有关 健康后果，关键是要确定连接日常情感体验的生理途径 痛苦，如对更广泛的心血管功能的负面情感反应。此外，随着个人地位的提高 在抑郁症状中，更有可能经历负性情感反应和心血管疾病 功能障碍、抑郁症状是一个关键的个体差异因素，可能会使个人 容易受到这些途径的影响。这种二次数据分析旨在对记忆缺失进行日常日记评估 以及它们对日常情绪的影响，以直接进行基于实验室的微血管功能评估。我们将使用 多层结构方程模型检验三个主要目标：1)检验日常生活的频率 记忆减退与交感-心血管功能障碍有关；2)检查负面情绪如何 对日常记忆丧失的反应与交感-心血管功能障碍有关；以及3)确定 抑郁症状的程度是否缓和了这些关系。此应用程序结合了创新的 方法允许更精确地测量日常记忆问题的体验和 导致一系列健康状况的生理过程，包括高血压、 抑郁障碍，最终导致阿尔茨海默氏症。这项工作利用了之前收集的数据来 高效地产生新的研究，帮助确定促进更健康的干预目标 认知老化可以在生命周期的早期实施，以防止认知衰退。

PROJECT SUMMARY The current project will examine whether and how negative affective responsivity to daily memory lapses is related to sympathetic-cardiovascular dysfunction in young, healthy adults. Daily memory lapses are a common, everyday experience that cause emotional distress among some adults regardless of age. Our previous work demonstrates that this emotional distress is heightened among young adults and persists even after accounting for other types of daily stress experiences (e.g., arguments or work stressors). Given that emotional distress in response to stressors is associated with a number of physical, emotional, and cognitive health consequences, it is critical to identify the physiological pathways that link daily experiences of emotional distress like negative affective responsivity to broader cardiovascular functioning. Further, as individuals higher in depressive symptoms are more likely to experience negative affective responsivity and cardiovascular dysfunction, depressive symptoms are a key individual difference factor that may make individuals more vulnerable to these pathways. This secondary data analysis aims to daily diary assessments of memory lapses and their impacts on daily emotions to direct lab-based assessments of micro-vascular functioning. We will use multilevel structural equation modeling to examine three primary aims: 1) examine how frequency of daily memory lapses relates to sympathetic-cardiovascular dysfunction; 2) examine how negative affective responsivity to daily memory lapses relates to sympathetic-cardiovascular dysfunction; and 3) determine whether level of depressive symptoms moderates these relations. This application combines innovative approaches that allow more precise measurement of both the experience of daily problems with memory and the physiological processes responsible for a wide range of health conditions including hypertension, major depressive disorder, and eventually Alzheimer’s disease. This work capitalizes on previously collected data to efficiently generate new research that will help identify intervention targets for the promotion of healthier cognitive aging that can be implemented earlier in the life span to prevent cognitive decline.