Daily stress processes and sympathetic reactivity in depression

抑郁症的日常压力过程和交感神经反应

• 批准号: 10218374
• 负责人: Jody Greaney
• 金额: $ 24.73万
• 依托单位: UNIVERSITY OF TEXAS ARLINGTON
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10218374
• 关键词: Acute; Adult; Affect; Affective; Behavior; Blood Pressure; Cessation of life; Chronic; Chronic stress; Clinical; Cognitive; Development; Dimensions; Disease; Emotional; Emotions; Ensure; Etiology; Event; Exposure to; Functional disorder; Future; Goals; Health; Heterogeneity; Individual; Intervention; Laboratories; Life; Link; Major Depressive Disorder; Measurement; Measures; Mediator of activation protein; Mental Depression; Mental Health; Minor; Nerve; Neurocognitive; Outcome; Parents; Pathogenesis; Pathogenicity; Pathologic; Physiological; Physiology; Play; Poverty; Predisposition; Prevalence; Prevention strategy; Process; Psychological Stress; Psychosocial Stress; Public Health; Regulation; Research Design; Research Domain Criteria; Role; Severities; Stress; Structure; Sympathetic Nervous System; Symptoms; System; Testing; Therapeutic; Therapeutic Intervention; acute stress; arterial stiffness; base; biological adaptation to stress; biosignature; burden of illness; cerebral microvasculature; cerebrovascular; clinically relevant; depressive symptoms; diaries; disability; disorder risk; insight; negative affect; neurovascular; novel; physical conditioning; pressure; preventive intervention; prospective; psychologic; psychological stressor; psychosocial stressors; resilience; response; stress reactivity; stressor; targeted treatment; treatment strategy; young adult

PROJECT SUMMARY/ABSTRACT Major depressive disorder (MDD) is a staggering public health challenge, manifesting in ~10% of adults in the US and contributing substantially to the global burden of disease and disability. Considering the increasing prevalence of MDD, particularly in young adulthood, it is critical to understand the pathophysiological underpinnings of MDD across a broad spectrum of function in order to identify individually-tailored preventive and therapeutic interventions. Given the intimate reciprocal link between stress and MDD, a better understanding of the mechanisms underlying stress system dysfunction in MDD may provide clinically relevant insight into such treatment strategies. The central scientific premise of this proposal is that MDD serves as a vulnerability factor that sensitizes and amplifies the functional link between daily psychosocial stress processes and acute sympathetic stress reactivity. Accordingly, determining the sympathetic neurovascular consequences of naturalistic daily psychosocial stress exposure may provide insight into the pathogenesis of MDD in stress- susceptible individuals, representing a novel biosignature of MDD. Aim 1 will examine the effect of daily psychosocial stress exposure on acute sympathetic stress reactivity in MDD. Aim 2 will determine the relation between negative affective reactivity to daily psychosocial stress exposure (i.e., increase in negative affect in response to stress) and acute sympathetic stress reactivity in MDD. Our integrative multi-pronged technical approach combines the comprehensive assessment of cumulative exposure and emotional responsiveness to naturalistic everyday psychosocial stressors (ambulatory daily diary-based approach) with the direct measurement of sympathetic reactivity (microneurography) during acute laboratory-applied emotional and cognitive stressors. Consistent with the Research Domain Criteria (RDoC) framework and to ensure the assessment of stress reactivity across a full spectrum of function, we will test adults with MDD having a broad range of symptom severity, as well as healthy non-depressed adults. Identification of the functional link between daily stressors and sympathetic reactivity in MDD is the necessary first step for future studies designed to examine novel targeted treatment and preventative strategies to induce emotional, cognitive, and physiological resilience to stress, thereby mitigating current—and reducing susceptibility toward future—psychiatric, cerebrovascular, and neurocognitive diseases.

项目概要/摘要 重度抑郁症 (MDD) 是一项令人震惊的公共卫生挑战，约 10% 的成年人患有重度抑郁症 (MDD) 美国对全球疾病和残疾负担做出了重大贡献。考虑到日益增加的 MDD 的患病率，特别是在年轻人中，了解其病理生理学至关重要 MDD 的基础涵盖广泛的功能，以便确定个性化的预防措施 和治疗干预。鉴于压力和 MDD 之间存在密切的相互联系，更好地理解 MDD 应激系统功能障碍的潜在机制可能为此类问题提供临床相关的见解 治疗策略。该提案的核心科学前提是 MDD 是一个脆弱性因素 使日常心理社会压力过程和急性应激反应之间的功能联系变得敏感和放大 交感应激反应。因此，确定交感神经血管的后果 自然的日常心理社会压力暴露可能有助于深入了解压力抑郁症的发病机制。 易感个体，代表 MDD 的新生物特征。目标 1 将检查每日的效果 心理社会压力暴露对 MDD 急性交感神经应激反应的影响。目标 2 将确定关系 负面情感反应与日常心理社会压力暴露之间的关系（即负面情绪的增加） MDD 中的应激反应）和急性交感神经应激反应。我们的综合多管齐下的技术 方法结合了累积暴露和情绪反应的综合评估 自然主义的日常心理社会压力源（基于动态每日日记的方法）与直接 在急性实验室应用的情绪和情绪反应过程中测量交感神经反应性（显微神经造影） 认知压力源。符合研究领域标准 (RDoC) 框架并确保 为了评估整个功能范围内的压力反应性，我们将测试患有重度抑郁症的成年人，其具有广泛的功能 症状严重程度范围以及健康非抑郁成年人。识别之间的功能联系 MDD 中的日常压力源和交感神经反应是未来研究的必要第一步 研究新的有针对性的治疗和预防策略，以诱导情绪、认知和生理 抗压能力，从而减轻当前的精神疾病并降低对未来的敏感性， 脑血管和神经认知疾病。