Asian American Prevention Research: A Populomics Epidemiology Cohort (ARISE)

项目摘要 我们建议将湾区基于人口的前瞻性队列贡献给一项全国性的队列研究 亚裔美国人(ASA)男性和女性在相关因素和决定因素的证据上存在重大差距 疾病风险和健康。我们将招募、描述和追随中国人、菲律宾人和越南人 美国人，三个未被充分研究的民族，他们的人口在美国迅速扩大 各州。具体地说，我们将招募2100名中国人、菲律宾人和越南裔美国人(每个民族700人 小组)在旧金山湾区进行心脏代谢特征和心理社会等方面的研究 通过广泛的调查、临床评估和分析、成像研究、多组学和 数字技术。尽管疾病模式和风险因素似乎在不同的ASA组之间有所不同， 先前的研究表明，只要受到糖尿病等心脏代谢障碍的高度影响， 高血压、血脂异常、心血管疾病、中风、非酒精性脂肪性肝病和肥胖，如 以及与移民创伤有关的被低估的精神健康状况和心理社会问题， 歧视和边缘化。然而，关于个别ASA群体的流行病学数据很少，而且 大多数临床指南和治疗方法都是基于高加索人的数据。我们的UG3/UH3研究站点 将与协调中心(U24)、其他研究地点和NHLBI合作，制定一大批 10,000名成员，以确定个别ASA族裔群体的风险因素和疾病模式。具体的 拟议研究的目的是：1)促进为#年的研究制定共同议定书 与NHLBI、U24和其他UG3/UH3调查人员合作，建立最先进的大众组学 队列；2)衡量基线自我报告的健康和危险因素以及临床的流行率或分布 每个种族组中的标记并跨种族组进行比较；以及3)确定 每个ASA族群的基线风险因素，包括自我报告的压力、睡眠和心率 来自可穿戴生物传感数据的可变性衍生的睡眠质量和压力，以及随后的(事件)健康 随访期间的结果。这项拟议的研究在深入揭示表型方面是创新的，通过 除传统风险外，还将包括对幸福感和焦虑的评估的全面调查 因素、基线临床评估、先进的数字技术和综合组学，以了解 流行病学、生物学、心理学和技术在身心健康方面的交叉。我们会 利用这些创新以及斯坦福大学在人口健康科学方面的世界级资源 发现关键的心脏代谢和心理社会因素潜在的健康和疾病以及.本研究 将促进健康和疾病的预防和治疗，并将导致改善健康和福祉 AAS的结果. 1

Project Summary We propose to contribute a Bay Area, population-based prospective cohort to a nationwide cohort study of Asian American (AsA) men and women to address major gaps in evidence on the correlates and determinants of disease risk and health. We will recruit, characterize, and follow Chinese, Filipino, and Vietnamese Americans, three understudied AsA ethnic groups whose populations are rapidly expanding in the United States. Specifically, we will recruit 2,100 Chinese, Filipino, and Vietnamese Americans (700 of each ethnic group) in the San Francisco Bay Area to characterize cardiometabolic profiles and psychosocial and other health factors through extensive surveys, clinical assessments and assays, imaging studies, multi-omics, and digital technology. Although disease patterns and risk factors appear to vary among different AsA groups, previous research suggests that AsAs are highly affected by cardiometabolic disorders such as diabetes, hypertension, dyslipidemia, cardiovascular disease, stroke, non-alcoholic fatty liver disease, and obesity, as well as underdiagnosed mental health conditions and psychosocial issues related to immigration trauma, discrimination, and marginalization. However, epidemiological data on individual AsA groups are sparse, and most clinical guidelines and treatments are based on data derived from Caucasians. Our UG3/UH3 study site will collaborate with the Coordinating Center (U24), other study sites, and NHLBI to develop a large cohort of 10,000 members to characterize risk factors and disease patterns in individual AsA ethnic groups. The specific aims of the proposed study are to 1) contribute to the development of a Common Protocol for the study in collaboration with NHLBI, U24, and other UG3/UH3 investigators and establish a state-of-the-art populomics cohort; 2) measure the prevalence or distribution of baseline self-reported health and risk factors and clinical markers in each ethnic group and compare across ethnic groups; and 3) determine relationships among baseline risk factors in each AsA ethnic group, including self-reported stress and sleep as well as heart rate variability-derived sleep quality and stress from wearable biosensing data, with subsequent (incident) health outcomes during follow-up. This proposed study is innovative in its in-depth exposome phenotyping through comprehensive surveys that will include assessments of well-being and anxiety in addition to traditional risk factors, baseline clinical assessments, advanced digital technology, and integrative omics to understand the intersections of epidemiology, biology, psychology, and technology in physical and mental health. We will leverage these innovations alongside Stanford’s world-class resources in population health sciences to uncover critical cardiometabolic and psychosocial factors underlying health and disease in AsAs. This study will advance health and disease prevention and treatment and will lead to improved health and well-being outcomes for AsAs. 1