Evaluation of radon progeny and air pollution effects in asthma

项目摘要/摘要 研究：众所周知，暴露在室内空气污染中的儿童更有可能患上哮喘，而在那些 哮喘，室内空气污染会加重哮喘症状。氡(Rn)，一种以肺闻名的放射性气体 癌症效应，衰变为辐射子代，一旦有可能导致细胞损伤 吸气。虽然住宅中的氡暴露很常见，但人们对氡的非癌症健康影响知之甚少。 腐烂产品。目前的卫生法规和优先事项完全基于其对肺部的致癌作用。 室内氡暴露最近与慢性阻塞性肺疾病的发病率和死亡率有关，而且 入院风险。考虑到住宅放射性暴露与COPD发病率之间的联系，在这篇文章中 探索性应用，我们通过粒子提出了与氡衰变产品相关的不良健康影响 哮喘发病率中的放射性，这是儿童人群中一种常见的阻塞性肺疾病。 候选人：班森博士的长期目标是成为一名由美国国立卫生研究院资助的独立研究员，专注于 评估物理环境的作用，特别关注内陆地区的空气污染和哮喘发病率 城市里的孩子。这项提案详细说明了一项为期五年的项目，为班松博士提供必要的培训和专业知识 通过测量健康效应来研究氡子体和颗粒物放射性在哮喘中的作用。 参加市内学校哮喘研究的内城哮喘儿童的既定队列(PI： Phipatanakul)。她的目标是找出导致哮喘的一种新的、可改变的环境暴露 儿童的发病率。这些发现有可能直接帮助设计公共卫生干预试验 通报作为减轻哮喘残疾的干预措施的减少氡的活动，并确定 与粒子放射性相关的生物标记物可能有助于表型患者并有助于预测 可能对基于生物标记物的个性化哮喘治疗有更有利的反应。 环境：班松博士将由流行病学、临床试验和治疗专家菲帕塔纳库尔博士指导 哮喘和变态反应性疾病的临床调查。她组建了一支非凡的顾问团队， 包括彼得罗斯·库特拉基斯博士、乔纳森·加芬博士和布雷特·库尔博士，他们投入了时间和资源， 和专业知识，以促进班森博士的职业发展和成功完成拟议的项目。 在此授勋期间，班森博士将通过哈佛商学院完成补充课程 公共卫生和哈佛大学催化剂计划，重点是磨练她在环境流行病学方面的技能 针对空气污染和儿童哮喘。导师、院校、 哈佛大学及其附属机构为她的研究提供了学习和合作的肥沃土壤。 Banzon博士将成为环境流行病学领域的专家，对 自然环境将把她塑造成一名成功的独立调查员。

PROJECT SUMMARY/ABSTRACT Research: Children exposed to indoor air pollution are known to more likely develop asthma, and in those with asthma, indoor air pollution can worsen asthma symptoms. Radon (Rn), a radioactive gas known for its lung cancer effects, decays into radiation-emitting progeny which has potential to induce cellular damage once inhaled. While residential Rn exposure is common, less is known about the non-cancer health effects of Rn decay products. Current health regulations and priorities are based solely on its carcinogenic effects in the lung. Indoor exposure to radon has been recently associated with COPD morbidity and mortality and an increased risk for hospital admissions. Given the association linking residential Rn exposure to COPD morbidity, in this exploratory application, we propose adverse health effects associated with Rn decay products via particle radioactivity in asthma morbidity, a common condition of obstructive lung disease in the pediatric population. Candidate: Dr. Banzon’s long-term goal is to become an independent NIH-funded investigator focused on the role of assessing the physical environment with a specific focus on air pollution and asthma morbidity in inner- city children. This proposal details a five-year project to provide Dr. Banzon the training and expertise necessary to study the effects of radon progeny and particle radioactivity in asthma by measuring its health effects in an established cohort of inner-city children with asthma enrolled in the School Inner-City Asthma Study (PI: Phipatanakul). Her aim is to identify a novel and modifiable environmental exposure that contributes to asthma morbidity in children. The findings have potential to aid in the design of public health intervention trials, directly inform activities regarding radon mitigation as an intervention to alleviate disability from asthma, and identify biomarkers associated with particle radioactivity which may help phenotype patients and help predict those who may have a more favorable response to personalized asthma treatment based on biomarkers. Environment: Dr. Banzon will be mentored by Dr. Phipatanakul, an expert in epidemiology, clinical trials, and clinical investigation in asthma and allergic diseases. She has assembled an extraordinary team of advisors, including Drs. Petros Koutrakis, Jonathan Gaffin, and Brett Coull, who have committed their time, resources, and expertise to facilitate Dr. Banzon’s career development and successful completion of the proposed project. During this award period, Dr. Banzon will complete complementary coursework through the Harvard School of Public Health and Harvard Catalyst Program, with a focus to hone on her skills in environmental epidemiology targeted toward air pollution and childhood asthma. The academic environment created by the mentor, institution, Harvard University, and its affiliates provides fertile ground for learning and collaborating specific to her research. Dr. Banzon will emerge an expert in the field of environmental epidemiology, with a unique understanding of the physical environmental that will shape her into a successful independent investigator.