Epigenetic Biomarkers of Postpartum Psychosis

摘要 生殖情绪发作，如产后抑郁症、经前焦虑症和 产后精神病是由女性生殖激素变化引发的情绪发作。我们有 先前在TTC 9 B和HP 1BP 3基因上发现了产后抑郁症的两个表观遗传生物标志物 在预测哪些妇女在产后会抑郁方面的准确率约为80%- 期我们最近发现这些生物标志物也与经前 当血液在月经周期的黄体期取样时，表明它们可能 是大脑对生殖激素波动敏感性的更普遍的生物标志物。该提案将采取 在荷兰从产后妇女中收集的独特血液样本的优势 精神病，并将确定我们的表观遗传生物标志物是否也与产后精神病有关。我们 还将进行全基因组微阵列分析，以确定表观遗传生物标志物， 特别是产后精神病产后精神病是一种严重的精神疾病， 产后即刻时间段。产后精神病几乎总是需要精神科住院治疗 同时也增加了自杀和自杀的风险。基于血液的生物标志物的鉴定， 预测产后精神病风险增加将允许采取预防措施， 在产后关键时期消除精神病急症并防止住院治疗。

Abstract Reproductive mood episodes, such as postpartum depression, premenstrual dysphoric disorder and postpartum psychosis, are mood episodes triggered by reproductive hormonal changes in women. We have previously identified two epigenetic biomarkers of postpartum depression at the TTC9B and HP1BP3 genes that are approximately 80% accurate in predicting which women will be depressed in the postpartum time- period. We have recently shown that these biomarkers are also associated with women that have premenstrual dysphoric disorder when blood is sampled in the luteal phase of the menstrual cycle indicating that they may be more general biomarkers of brain sensitivity to reproductive hormone fluctuations. This proposal will take advantage of a unique sample of blood specimens collected in the Netherlands from women with Postpartum Psychosis and will determine if our epigenetic biomarkers are also associated with Postpartum Psychosis. We will also conduct a genome wide microarray analyses in order to identify epigenetic biomarkers that are specific to Postpartum Psychosis. Postpartum psychosis is a serious psychiatric illness with acute onset in the immediate postpartum time period. Postpartum Psychosis almost always requires psychiatric hospitalization and carries with it an elevated risk of suicide and infanticide. Identification of blood-based biomarkers that are predictive of an increased risk for Postpartum Psychosis would allow for preventative measures which may eliminate a psychiatric emergency and prevent hospitalization during the critical postpartum time period.