Auditory cortex asymmetry in normals and schizophrenics

描述（由申请人提供）：人类大脑皮层具有明显的语言功能半球不对称性。上级颞平面的解剖不对称性可能与语言功能有关。然而，详细的解剖不对称的细胞结构特征知之甚少，我们建议利用最近开发的免疫细胞化学工具，以确定听觉区域的上级颞平面，并确定他们是否有可靠的细胞结构不对称。 改变的不对称的上级颞平面是一个功能的神经和精神疾病。精神分裂症患者大脑的特征是半球不对称性的改变，尤其是在上级颞平面。此外，有证据表明精神分裂症患者大脑中的神经元密度和神经元迁移发生了改变，但尚不清楚这些变化是否与半球不对称性的改变有关。我们建议测量识别区域的体积，以及这些区域中灰质和白色物质中的神经元密度，以确定这些特征在正常大脑中是否不对称分布，以及它们在精神分裂症大脑中是否发生了变化。

DESCRIPTION (provided by applicant): The human cerebral cortex has a pronounced hemispheric asymmetry for language function. The superior temporal plane has anatomical asymmetries that might correlate with language function. However, the detailed cytoarchitectonic features of the anatomical asymmetry are poorly understood, We propose to take advantage of recently developed immunocytochemical tools to identify auditory regions of the superior temporal plane, and to determine if they have reliable cytoarchitectonic asymmetries. Altered asymmetry of the superior temporal plane is a feature of neurological and psychiatric diseases. Schizophrenic brains are characterized by alterations in hemispheric asymmetry that are especially pronounced in the superior temporal plane. Additionally, there is evidence for altered neuron density and neuron migration in the schizophrenic brain, but it is unknown if these changes correlate with the altered hemispheric asymmetry. We propose to measure the volume of identified areas, and the neuron densities in the gray matter and white matter in those areas, to determine if these features are asymmetrically distributed in normal brains, and if they are changed in the schizophrenic brains.