Personality Disorder Over 20yrs: Risks, Course & Impact

描述（由申请人提供）：拟进行的研究扩展了一项纵向研究，研究对象为784人，这些人自1975年以来一直被研究，评估时平均年龄为38岁。该队列最初是随机抽样的，并一直密切代表其抽取的年龄组和地理区域。独特的是，人格障碍（pd）自青春期早期就被评估，与轴一障碍一起，以及广泛的风险和结果。在27份出版物中（153份来自社区儿童研究的出版物或出版物中），pd已被证明与许多儿童风险有关，反过来，pd构成了随后的轴I疾病和严重功能损害的独特风险。拟研究的目的是调查：PD症状和障碍在中年的患病率和持续性的变化；既往和当前PD对成人功能、健康和保健的影响；I轴障碍与PD的潜在关系特定遗传差异与PD及其相关功能的关系PD及其改变的环境和体验性危险因素；风险/基因相互作用预测帕金森病的发病率和病程父母PD对养育子女和后代的影响。

DESCRIPTION (provided by applicant): The proposed study extends a longitudinal study of 784 persons who have been studied since 1975, and who will be an average age of 38 when assessed. The cohort was originally randomly sampled, and has remained closely representative of the age group and geographical area from which it was drawn. Uniquely, personality disorders (PDs) have been assessed since early adolescence, in conjunction with the Axis I disorders, and a broad range of risks and outcomes. In 27 publications (of 153 published or in press from the Children in the Community study) PDs have been shown to be related to a number of childhood risks and, in turn, to constitute unique risks for both subsequent Axis I disorders and for serious impairment in function. The aims of the proposed research are to investigate: Changes in the prevalence and persistence of PD symptoms and disorders in mid-adulthood; Impact of previous and current PD on adult function, health, and health care; Prospective relationships between Axis I disorders and PD; Relationship of specific genetic differences to PD and related functioning; Environmental and experiential risk factors for PD and PD change; Risk/ gene interaction in predicting prevalence and course of PD; Impact of parental PD on parenting and on offspring.