Hawaiian, Asian American, and Pacific Islander (HAAPI) Coordinating Center

总结/摘要 亚裔、夏威夷人或太平洋岛民（AsA-NHPI），占美国人口的7.7%。 在NIH资助的前瞻性流行病学研究中，作为 因此，我们对心血管、代谢和心血管疾病的负担和原因的认识存在很大差距。 这些人群中的精神疾病。这些背景的个人经历过，以不同的 其他少数群体所经历的障碍、压力和陈规定型观念，同时也面临挑战， 对他们来说是独一无二的。了解他们生活方式的多样性以及社会和环境 环境，以及他们的祖先，是决定他们的健康需求和如何 解决他们。这些人群的异质性，纵向上与其他人群相比， 人口，可能会增加独特的见解的病因学的身体和精神健康状况。在这 申请夏威夷，亚裔美国人和太平洋岛民协调中心（HAAPI-CC），我们 建议：（1）将卓越的科学，统计和文化专业知识用于评估 夏威夷人、亚洲人和太平洋岛民的身心健康及其决定因素; (2)提供运营、数据科学和生物储存库基础设施和领导力，以支持 科学优先级的同龄人，并刺激和加强辅助学习机会广泛;（3） 协调和支持临床或社区现场中心（CCFC）的活动，以加强招聘和 （4）加强早期职业发展 调查人员，特别是那些来自代表性不足的背景。通过这项工作，我们可以估计 心血管疾病患病率和风险因素以及心理健康状况，研究它们之间的相互作用， 轨迹随时间的变化，并检查与数据链接产生的新暴露的关联， 生物标本我们预计将领导一些辅助研究，以获得更多的丰富数据，从新的 来源（可穿戴设备，mHealth，基因组学，蛋白质组学，代谢组学，微生物组学，心脏和大脑成像）。 通过这些努力，我们和我们的CCFC同事，将提高对健康状况的认识， 亚洲人、夏威夷人和太平洋岛民，并为更深入地了解他们的 生物学、环境学和社会学基础。 ,

SUMMARY/ABSTRACT People of Asian, Hawaiian, or Pacific Islander (AsA-NHPI) ancestry, while representing 7.7% of the US population, have been largely underrepresented from NIH-funded prospective epidemiologic studies. As a result, there are large gaps in our knowledge of the burden and causes of cardiovascular, metabolic, and mental health disorders in these populations. Individuals of these backgrounds have experienced, to varying degrees, the barriers, stresses, and stereotyping experienced by other minorities while also having challenges that are unique to them. Understanding the heterogeneity of their lifestyles and societal and environmental circumstances, as well as their ancestry, is a critical first step in determining their health needs and how to address them. The heterogeneity in these populations, followed longitudinally and contrasted with other populations, may add unique insights into the etiology of both physical and mental health conditions. In this application for the Hawaiian, Asian American, and Pacific Islander Coordinating Center (HAAPI-CC), we propose to: (1) Bring exceptional scientific, statistical, and cultural expertise to the effort of assessing the physical and mental health and their determinants in people of Hawaiian, Asian, and Pacific Islander ancestry; (2) Provide the operational, data science, and biorepository infrastructure and leadership to support the scientific priorities of the cohort and stimulate and enhance ancillary study opportunities broadly; (3) Coordinate and support Clinical or Community Field Center (CCFC) activities to enhance recruitment and retention and broader community engagement; and (4) Enhance career development of early stage investigators, particularly those from under-represented backgrounds. Through this effort, we can estimate the prevalence of cardiovascular diseases and risk factors and mental health conditions, study their interplay and trajectories over time, and examine associations with novel exposures derived from data linkages and biospecimens. We anticipate leading a number of ancillary studies to obtain additional rich data from novel sources (wearables, mHealth, genomics, proteomics, metabolomics, microbiome, cardiac and brain imaging). Through these efforts, we and our CCFC colleagues, will advance the knowledge of the health conditions of Asian, Hawaiian, and Pacific Islanders and provide the infrastructure for deeper understanding of their biological, environmental, and sociological underpinnings. ,