Women's Health Initiative Cancer Survivor Cohort

妇女健康倡议癌症幸存者队列

• 批准号: 8440873
• 负责人: GARNET L. ANDERSON
• 金额: $ 189.48万
• 依托单位: FRED HUTCHINSON CANCER RESEARCH CENTER
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-02-15 至 2018-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8440873
• 关键词: Address; Aging; Algorithms; Biological Markers; Blood specimen; Cancer Burden; Cancer Research Network; Cancer Survivor; Cancer Survivorship; Chronic Disease; Clinical; Colorectal; Colorectal Cancer; Comorbidity; Coupled; DNA; Data; Data Collection; Data Set; Databases; Diagnosis; Endometrial; Endometrial Carcinoma; Ensure; Epidemiological Factors; Genetic Markers; Health; Health Maintenance Organizations; Heterogeneity; Incidence; Intervention; Laboratories; Length; Lung Lymphoma; Lymphoma; Malignant Neoplasms; Malignant neoplasm of lung; Malignant neoplasm of ovary; Medical Records; Medicare; Methods; Molecular; Outcome; Ovarian; Paraffin Embedding; Patient Outcomes Assessments; Phenotype; Plasma; Population; Population Study; Postmenopause; Quality of life; Quality-of-Life Assessment; Records; Recurrence; Research; Research Personnel; Resources; Risk Factors; Sampling; Source; Specimen; Speed; Surveys; Survivors; Techniques; Translations; Treatment outcome; Tumor Tissue; Ursidae Family; Vial device; Woman; Women' s Health; administrative database; aging population; base; biobank; cancer diagnosis; cancer recurrence; cancer site; cancer therapy; cohort; cost; demographics; follow-up; leukemia; leukemia/lymphoma; lifestyle factors; malignant breast neoplasm; melanoma; molecular marker; neoplasm registry; outcome forecast; population based; pre-clinical; programs; randomized trial; repository; success; survivorship; tumor

DESCRIPTION (provided by applicant): The Women's Health Initiative represents a large population-based sample of 161,000 postmenopausal US women. These women have been well-characterized in terms of demographics, diverse exposures, quality of life assessments and incidence of chronic diseases, including over 20,000 incident invasive cancers over a mean 12 years of follow-up. A biorepository maintains >5 million vials of serum, plasma and DNA, and over 93,000 women continue in active follow-up. WHI investigators seek to enhance opportunities for cancer survivorship studies, particularly those that recognize the import of molecular heterogeneity of tumors, by addressing two key limitations in the existing program. Specifically, we propose to; 1) collect information on cancer treatment, clinical outcomes (recurrence) and patient reported outcomes in women diagnosed with selected cancers (breast, colorectal, endometrial, lung, and ovarian cancers, lymphoma, leukemia, and melanoma, projected n=21,882) during WHI participation using Medicare linkages or direct medical record abstraction; and 2) collect paraffin-embedded tumor tissue from selected cancers (colorectal and ovarian cancers, melanoma, lymphoma, and breast and lung cancer subtypes, projected n=5,900). We will collect treatment and outcome data via linkage to Medicare datasets for cost efficiencies, whenever possible, and will pursue and evaluate methods to collect these data through access to other administrative databases. By enhancing the WHI database with cancer treatment and recurrence data, WHI will be a valuable resource to examine the effects of cancer diagnosis and treatment on overall health and quality of life in an aging cohort-one that represents the fastest growing population, bears the great cancer burden but has been under-represented in randomized trials. By supplementing the specimen repository with tumor specimens, the WHI Program will be able to support "up-to-date" phenotyping of cancers and contribute to our understanding of the molecular basis of cancer, its treatment and survival. We want to begin soon to ensure that a large and representative resource can be realized, because tumor tissue and records for cases diagnosed in the early period of the WHI will become increasingly difficult to obtain.

描述（由申请人提供）：妇女健康倡议代表了 161,000 名绝经后美国妇女的大量人口样本。这些女性在人口统计、多样化的暴露、生活质量评估和慢性疾病发病率方面具有良好的特征，其中包括在平均 12 年的随访中超过 20,000 起侵袭性癌症事件。生物样本库保存着超过 500 万瓶血清、血浆和 DNA，超过 93,000 名女性继续积极随访。 WHI 研究人员寻求通过解决现有计划中的两个关键限制来增加癌症生存研究的机会，特别是那些认识到肿瘤分子异质性重要性的研究。具体来说，我们建议： 1) 使用 Medicare 链接或直接病历提取，收集参与 WHI 期间被诊断患有选定癌症（乳腺癌、结直肠癌、子宫内膜癌、肺癌和卵巢癌、淋巴瘤、白血病和黑色素瘤，预计 n=21,882）的女性的癌症治疗、临床结果（复发）和患者报告结果的信息； 2) 从选定的癌症（结直肠癌和卵巢癌、黑色素瘤、淋巴瘤以及乳腺癌和肺癌亚型，预计 n=5,900）中收集石蜡包埋的肿瘤组织。我们将尽可能通过与医疗保险数据集的链接来收集治疗和结果数据，以提高成本效率，并将寻求和评估通过访问其他管理数据库来收集这些数据的方法。通过利用癌症治疗和复发数据增强 WHI 数据库，WHI 将成为检查癌症诊断和治疗对老龄化人群整体健康和生活质量影响的宝贵资源，该人群代表了增长最快的人口，承受着巨大的癌症负担，但在随机试验中代表性不足。通过用肿瘤标本补充标本库，WHI 计划将能够支持癌症的“最新”表型分析，并有助于我们了解癌症的分子基础、其治疗和生存。我们希望尽快开始，以确保能够实现大量且具有代表性的资源，因为获得 WHI 早期诊断病例的肿瘤组织和记录将变得越来越困难。