Multimodality Deep Phenotyping of Postural Orthostatic Tachycardia Syndrome (POTS)

项目总结 体位直立性心动过速综合征(POTS)是一种慢性疾病，会导致残疾症状和 生产力的大幅下降。并不是所有的POTS患者都是相同的，其原因和意义也不同 亚型未知。例如，一些患者可能在免疫系统调节异常的同时 其他人可能在肌肉对运动的反应上有问题。运动训练已被证明是一种 对POTS有利的治疗，但约25%的患者无法完成锻炼计划。 我们的研究将通过系统和全面的研究来考察不同类型的锅 一大群不同的病人。这将包括对症状、血液测试和心脏结构的仔细评估。 以及对肌肉对运动的反应的详细分析。这项研究将是第一个定义全貌的研究 不同的POTS子类型以及这些子类型之间的关系。我们的研究将使临床医生能够更好地 评估和个体化治疗，并将指导未来的POTS研究。

Project summary Postural orthostatic tachycardia syndrome (POTS) is a chronic disorder causing disabling symptoms and substantial loss of productivity. Not all POTS patients are the same, and the causes and significance of different subtypes are not known. For example, some patients may have abnormal regulation of their immune system while others may have problems with the response of their muscles to activity. Exercise training has been shown to be a beneficial treatment for POTS, but about 25% of patients are unable to complete the exercise program. Our research study will examine the different types of POTS by systematically and comprehensively studying a large diverse group of patients. This will include careful assessment of symptoms, blood tests, and heart structure as well as a detailed analysis of the muscle response to exercise. This study will be the first to define the full picture of different POTS subtypes and the relationship between these subtypes. Our studies will allow clinicians to better evaluate and individualize treatment and will guide future POTS research.