WIHS Data Management and Analysis Center (WDMAC)

描述（改编自申请书，第328页）：本提案的目的是证明，在有效治疗的时代，与艾滋病毒感染妇女的自然史相关的关键假设可以通过对参加妇女机构间艾滋病毒研究（WIHS）的个人进行持续随访来最好地解决。成立于1993年，研究美国妇女的艾滋病，WIHS已经组建了一个经验丰富的研究网络和广泛的基础设施，作为尖端实验室和临床科学的平台。参与者包括传统上研究不足的人群，但WIHS已经制定了有效的战略，成功地保持保留和后续行动，从而确保其长期特征和确定的结果。为了利用定期访视时收集的综合数据，采用了最先进的分析方法，以评估治疗开始前后收集的因素与广泛的有益和不良结局的相关性。除了测试作为核心WIHS研究的一部分的重要假设外，我们还创建了一个数据和样本的研究平台，构成了当前和未来研究的重要工具。该平台允许WIHS社区内外的研究人员使用纵向收集的数据和样本来测试新的假设，从而避免重新编制所需资源的成本。该研究具有高度的协作性，与众多研究者共享数据和标本，这些研究者通过研究者发起的研究（R 01和其他机制）获得资助，并通过WIHS相关的早期职业发展奖支持新的临床科学家。其中每一个要素都有助于持续的生产力，截至本报告提交时，约有320份出版物。WIHS的科学和业务组成部分是复杂和动态的。本申请的A部分将描述自2002年3月我们上次提交以来所取得的队列和关键科学成就;介绍我们的科学和组织结构;以及我们提出的科学假设和2007-2012年的研究议程，该议程分为四个相互关联的研究项目和六个核心。

DESCRIPTION (adapted from application, page 328): The purpose of this proposal is to demonstrate that key hypotheses related to the natural history of HIV-infected women in the era of potent therapy can be best addressed through continued follow up of individuals enrolled in the Women's Interagency HIV Study (WIHS). Established in 1993 to study HIV disease among women in the U.S., the WIHS has assembled an experienced research network and an extensive infrastructure that serves as a platform for cutting-edge laboratory and clinical science. Participants encompass a traditionally understudied population, yet WIHS has developed effective strategies to successfully maintain retention and follow up, thus ensuring their long-term characterization and the ascertainment of outcomes. To capitalize upon the comprehensive data collected at regularly scheduled visits, state-of-the art analytical approaches have been implemented to assess the association of factors collected prior to and after therapy initiation with a broad spectrum of beneficial and adverse outcomes. In addition to testing important hypotheses as part of the core WIHS study, we have created a research platform of data and specimens that constitutes an important tool for current and future studies. This platform permits investigators inside and outside the WIHS community to use longitudinally collected data and specimens to test new hypotheses, and thus avoid the costs of compiling needed resource de novo. The study has been highly collaborative, sharing data and specimens with a multitude of investigators funded through investigator-initiated studies (R01s and other mechanisms) and in supporting new clinical scientists via WIHS linked early career development awards. Each of these elements has contributed to continued productivity, with some 320 publications as of this submission. The scientific and operational components of the WIHS are complex and dynamic. Part A of this application will describe the cohort and key scientific achievements that have occurred since our previous submission in March 2002; a presentation of our scientific and organizational structure; and our proposed scientific hypotheses and a research agenda for 2007-2012 that has been organized into four interrelated research projects and six cores.