Human Decidual Lymphocytes and their Placental Ligands

这项研究的具体目的是检查人类蜕膜的受体、配体和功能。 淋巴细胞，以期了解它们在着床和妊娠中可能扮演的角色。特别是，我们 希望如此。“ 。检测人类蜕膜过度表达的新蛋白的生化和可能的功能 可能参与下调免疫反应的自然杀伤(NK)细胞，以继续分析 研究这些细胞的转录谱，并研究它们的细胞毒性和分泌细胞因子的能力。 。通过研究不变NKT(INKT)细胞与CDLD的相互作用来评价其在蜕膜中的作用 在几种细胞类型上表达，通过检测它们的V_谱系与细胞因子分泌的关系，通过测试 假设它们的功能是调节母胎界面的免疫反应，并通过 检查他们完整的转录特征。 。蜕膜NK和iNKT类MHC蛋白配体在胎盘中的表达 检测胎盘绒毛外细胞滋养细胞与GM-CSF受体的相互作用。 NK、iNKT细胞和GM-CSF。

The specific aims of this research are to examine the receptors, ligands, and functions of human decidual lymphocytes with a view to understanding their possible roles in implantation and pregnancy. In particular, we wish." . To examine the biochemistry and possible functions of novel proteins overexpressed by human decidual natural killer (NK) cells that may be involved in down-modulation of the immune response, to continue analysis of the transcriptional profiles of these cells and to study their cytoxicity and ability to secrete cytokines. . To assess the role of invariant NKT (iNKT) cells in the decidua by studying their interaction with CDld expressed on several cell types, by examining the relation of their V_ repertoire to cytokine secretion, by testing the hypothesis that they function to regulate the immune response at the maternal-fetal interface and by examining their complete transcriptional profiles. . To examine the expression in the placenta of putative Class I MHC protein ligands for decidual NK and iNKT cells and of the GM-CSF receptor and to examine the interaction of placental extravillous cytotrophoblasts with NK and iNKT cells and with GM-CSF.