2/2 Drug Development and Capacity Building: A UCR/CoH-CCC Partnership

美国(美国)50多年来一直领导着世界上的药物发现。虽然这是一个重要的 成就，美国的药物几乎只在非西班牙裔欧洲人身上进行优化和测试- 美国人，对有色人种男性或女性的评估最低。因此，在非 拉美裔欧洲裔美国人(盎格鲁人)，可能在大多数情况下具有意想不到的毒性或疗效降低 世界人口。美国药物开发的差异贯穿于整个药物发现流程。 只有一小部分基础科学家是拉丁裔/西班牙裔或非裔美国人。最初的药物开发和 在从盎格鲁人衍生的细胞系中进行优化。不到2%的医生进行临床试验 是拉丁裔/西班牙裔或非裔美国人。大多数临床试验参与者都是盎格鲁人。然而，新药是FDA 批准用于拉美裔/西班牙裔-和非裔美国人/非洲人，而没有进行足够的测试。这是不可接受的 药物只由我们的一小部分公民开发和优化。在这个U54合作伙伴关系中，我们的目标是 开发资源、基础设施和培训以指导下一代研究人员，以反映 我们的集水区的多样性。在我们成功的P20赠款的基础上，在这个U54合作伙伴关系中，UCR和 CoHCCC的目标是发展合作、资源和培训计划，以减少药物差距 药物开发贯穿于整个药物开发流水线。我们的目标是让这个项目成为焦点 UCR和CoHCCC指导和培训不同的癌症生物学家力量并解决差异 在癌症治疗和药物开发方面。我们的P20已经促进了R01资助、K01资助和 博士后/博士后奖学金。这两家机构都高度致力于-CoHCCC为我们的 P20赠款，并将每年捐赠25万美元，以确保这一U54伙伴关系的成功。目标1将加强 UCR的癌症研究能力和开发资源，以提高UCR/CoHCCC的联合开发能力 为我们集水区的不同人群优化的治疗药物。目标2将增加容量 UCR和CoHCCC联合开发针对影响不同个体生存差异的药物 生活在我们的南加州社区。目标3将提供培训、机会和指导 确保下一代治疗科学家和临床试验人员反映南方的多样性 加利福尼亚。

The United States (U.S.) has led the world in drug discovery for over 50 years. While this is a significant accomplishment, U.S. drugs have been almost exclusively optimized and tested in non-Hispanic European- Americans and been minimally evaluated in men- or women-of-color. As a result, drugs that work well in non- Hispanic European-Americans (Anglos), may have unexpected toxicity or decreased efficacy in most of the world’s population. Disparities in U.S. drug development occur throughout the entire drug discovery pipeline. Only a small number of basic scientists are Latino/Hispanic- or African-American. Initial drug development and optimization takes place in cell lines derived from Anglos. Less than 2% of physicians conducting clinical trials are Latino/Hispanic- or African-American6. Most clinical trials participants are Anglos. Yet, new drugs are FDA approved for Latinos/Hispanics- and African-Americans/Africans without sufficient testing. It is unacceptable that drugs are developed by, and optimized for, only a fraction of our citizens. In this U54 partnership we aim to develop the resources, infrastructure, and training to mentor the next generation of researchers that reflect the diversity of our Catchment Area. Building on our successful P20 grant, here in this U54 partnership, UCR and CoHCCC aim to develop the collaborations, resources, and training programs to reduce disparities in drug development throughout the entire drug development pipeline. Our goal is for this program to become a focal point for UCR and CoHCCC to mentor and train a diverse force of cancer biologists and address the disparities in cancer therapeutics and drug development. Already, our P20 has fostered joint R01 grants, K01 grants, and pre-/post-doctoral fellowships. Both institutions are highly committed - CoHCCC contributed over $800K to our P20 grant and will contribute $250K/year to ensure the success of this U54 partnership. Aim 1 will strengthen UCR’s cancer research capacity and develop the resources to increase UCR/CoHCCC’s ability to jointly develop therapeutic agents optimized for the diverse populations in our catchment area. Aim 2 will increase the capacity of UCR and CoHCCC to jointly develop drugs that target disparities in survival affecting the diverse individuals living in our Southern California communities. Aim 3 will provide the training, opportunity, and mentorship to ensure that the next generation of therapeutic scientists and clinical trialists reflect the diversity of Southern California.