Nitric oxide Releasing Ultra-Slippery Antibacterial Surfaces for Urological Catheter Applications

摘要 导尿管是医院环境中使用最广泛的医疗器械之一， 由于人口老龄化而增加。在各种常用的生物医学设备中， 在临床环境中，导尿管与最大部分的医疗并发症有关， 感染导尿管相关性尿路感染（CITTI）占所有医疗保健的近40% 相关感染（HAI），并可能导致患者住院时间延长，进而导致更高的 医疗费用。为了克服这种感染的风险，导管表面能够防止细菌粘附 和生物膜形成，同时消除存在于附近的浮游细菌， 令人向往然而，没有长期的导管解决方案能够实现这一目标。Nytricx，Inc.具有 开发专有方法和专有技术，开发抗感染的一氧化氮（NO）释放界面 能够有效消除多种细菌菌株，同时不引起细胞毒性反应， 从哺乳动物细胞系。Nytricx，Inc.还证明了硅油的液体注入，以产生 超滑表面能够防止蛋白质和细菌的粘附，从而消除生物膜。一 通过组合液体注入策略和NO释放聚合物实现协同抗微生物反应 （LINORel）.这一阶段SBIR应用的总体目标是创造一种长期的高抗菌性 导尿管通过浸渍Foley导管与NO供体，S-亚硝基-N- 乙酰青霉胺（SNAP）与液体注入硅油界面，并评价商业化 在机械和生物性能方面的可行性。

Abstract Urinary catheters are one of the most widely used medical devices in a hospital setting and are expected to only increase in growth due to the aging population. Out of all the various biomedical devices that are frequently used in a clinical setting, urinary catheters are associated with the largest portion of medical complications related to infection. Catheter associated urinary tract infections (CAUTIs) account for nearly 40% of all healthcare associated infections (HAIs) and can lead to extended hospital stays for patients which in turn leads to higher healthcare costs. To overcome this risk of infection, a catheter surface that is able to prevent bacterial adhesion and biofilm formation while simultaneously eliminating planktonic bacteria present in the vicinity is highly desirable. However, no long-term catheter solution has been able to accomplish this goal. Nytricx, Inc. has developed proprietary methods and know-how developing anti-infective nitric oxide (NO) releasing interfaces capable of effectively eliminating a wide variety of bacterial strains while being able to elicit no cytotoxic response from mammalian cell lines. Nytricx, Inc. has also demonstrated that the liquid-infusion of silicone oil to create a super slippery surface is able to prevent the adhesion of proteins and bacteria and thus eliminate biofilms. A synergistic antimicrobial response is achieved by combining liquid-infused strategy and NO releasing polymers (LINORel). The overall objective of this Phase I SBIR application is to create a long-term highly antimicrobial urinary catheter through a combination of impregnating Foley catheters with a NO donor, S-nitroso-N- acetylpenicillamine (SNAP), with a liquid-infused silicone oil interface and to evaluate commercialization feasibility in terms of mechanical and biological properties.