Shared Resource Core: Puerto Rico BioBank

摘要|波多黎各生物库 波多黎各生物银行（PRBB）庞塞健康科学大学莫菲特癌症共享资源 中心（PHSU-MCC）合作伙伴收集，处理，注释，存储和分发生物标本， 临床人口统计学数据，用于癌症研究。截至2022年8月，PRBB 已经同意了4，097名受试者，代表42种不同的癌症类型和健康个体。从这些 受试者中，完成了1，899例临床病史和人口统计学调查，并采集了8，453份生物标本。 收集。组织、衍生分析物（例如，DNA/RNA）、数据和组织微阵列已分发给 支持出版物和赠款提交的研究项目。PRBB促进了 与研究教育核心（REC）合作，为医学生提供生物库见习， 与外联方案合作，为坦帕和庞塞的H/L社区的教育工作做出了贡献 核心（OC）。与定量科学核心（QSC）一起，PRBB已同意142名H/L患者， ORIEN-Avatar网络（https：www.oriencancer.org）改善了H/L组织在此 致力于加速发现新的靶向癌症治疗方法的网络，目前只有7.2%。 PRBB参加了包括REBLAC（拉丁美洲和加勒比生物库）在内的国际财团 网络），PRACTICAL（前列腺癌协会小组调查癌症相关的变化， 基因组），LAGENO-BC（拉丁美洲乳腺癌基因组学联盟），拉丁美洲结直肠癌 联盟（LC 3），乳腺癌遗传学的汇合项目。PRBB的目标是解决 癌症健康差异的关键未满足的需求，缺乏H/L患者的全面代表性， 分子数据集的水平与该人群中癌症的患病率一致。目标是：1）支持 通过有针对性地招募选定癌症类型的患者沿着非癌症对照来开展研究项目。 招聘既广泛，以建立一个全面的数据库，为未来的项目，并侧重于目前 提出了前列腺癌和卵巢癌的全面研究项目。我们将继续优化患者的物流 在合作医生的办公室和圣卢卡斯医院（SLH）进行教育和同意，并保持 与项目PI保持联系。2)通过开发创新资源和服务支持研究。我们将 注重开发研究人员可以迅速获得的新的研究资源和服务。这 包括构建注释良好的组织微阵列，代表显著影响H/L的癌症类型， （前列腺，卵巢），扩大分子表型（exomeSeq，RNAseq，祖先）与 ORIEN利用了识别与患者分子特征相匹配的临床试验的潜力， 并利用我们在类器官和患者源性异种移植模型方面的新兴专业知识来支持项目。第三章 与教育、外联和社区教育方面的伙伴关系组成部分合作， 组织捐赠，并提高QSC的数据可用性。

ABSTRACT | PUERTO RICO BIOBANK The Puerto Rico BioBank (PRBB) Shared Resource of the Ponce Health Sciences University-Moffitt Cancer Center (PHSU-MCC) Partnership collects, processes, annotates, stores, and distributes biospecimens and clinical-demographic data for investigator-initiated translational cancer research. As of August 2022, the PRBB has consented 4,097 subjects representing 42 different cancer types and healthy individuals. From these subjects, 1,899 clinical history and demographic surveys were completed and 8,453 biospecimens were collected. Tissues, derivative analytes (e.g., DNA/RNA), data, and tissue microarrays have been distributed to research projects supporting publications and grant submissions. The PRBB contributed to the development of a Biobanking clerkship for medical students in collaboration with the Research Education Core (REC) and contributed to education efforts in H/L communities in both Tampa and Ponce in collaboration with the Outreach Core (OC). Together with the Quantitative Sciences Core (QSC), the PRBB has consented 142 H/L patients to the ORIEN-Avatar network (https://www.oriencancer.org) improving the representation of H/L tissues in this network, dedicated to accelerating the discovery of novel targeted cancer treatments, that is currently only 7.2%. The PRBB participates in international consortia including REBLAC (Latin American and Caribbean Biobanking network), PRACTICAL (Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome), LAGENO-BC (Latin America Genomics of Breast Cancer Consortium), the Latino Colorectal Cancer Consortium (LC3), the Confluence Project for Breast Cancer Genetics. The objective of the PRBB is to address the critical unmet need in cancer health disparities of a lack of representation of H/L patients in comprehensive molecular datasets at levels that align with the prevalence of cancer in this population. The aims are: 1) Support research projects by targeted recruitment of patients of selected cancer types along with non-cancer controls. Recruitment is both broad to build a comprehensive database for future projects and focused on the currently proposed full research projects in prostate and ovarian cancer. We will continue to optimize the logistics of patient education and consenting at collaborating physician’s offices and San Lucas Hospital (SLH) and by maintaining constant contact with Project PIs. 2) Support research by developing innovative resources and services. We will focus on developing new research resources and services that can be rapidly accessed by researchers. This includes building well-annotated tissue microarrays representing cancer types that significantly impact H/Ls (prostate, ovarian), expanding molecular phenotyping (exomeSeq, RNAseq, ancestry) in collaboration with ORIEN, tapping into the potential for identifying clinical trials that are matched to a patient’s molecular profile, and leverage our emerging expertise in organoid and patient-derived xenografts models to support projects. 3) Collaborate with partnership components in education, outreach, and community education on the importance of tissue donation, and improving data availability with the QSC.