Stimulus- Evoked Vestibular Evaluation System

描述(由申请人提供)：Vesticon正在开发一种刺激诱发前庭评估系统(SEVE)，用于检测/分析导致头晕或失衡的情况的声音和压力诱发表现，供医疗机构应用。这种情况在所有导致头晕/失衡的疾病中占了相当大的一部分。总体而言，头晕和失衡障碍长期影响着620万美国人，与平衡相关的跌倒占老年人意外死亡的一半以上。虽然可以进行治疗，但诊断是一个重大问题，其原因和症状多种多样，需要先进技术来协助检测/分析。目前的技术仅限于功能单一、操作困难、不可解释的产品，既不全面，也不省时。SEVE将自动化诊断和本地化测试，这些测试在文献中是众所周知的，但由于实用性以及缺乏标准化和培训，往往被打折、执行不正确或根本不执行。 最近，我博士的工作已经完成，我们开发了一个工作原型，在一个小的受试者队列中展示了SEVE的价值，并评估了用户友好性。对于Ph.II，我们预计将开发几个新的协议，添加额外的测试和功能，工程修改，用于诊断协议的增强软件，解释，用于决策支持的综合分析，以及在PI的诊所和两个独立站点评估Seve的受试者群体的表现。

DESCRIPTION (provided by applicant): Vesticon is developing a Stimulus-Evoked Vestibular Evaluation System (SEVE) for detection/analysis of sound and pressure evoked manifestations of conditions causing dizziness or imbalance for application at medical facilities. Such conditions comprise a significant portion of all disorders resulting in complaints of dizziness/imbalance. In all, dizziness and imbalance disorders chronically affect 6.2 million Americans, where balance-related falls account for more than half of accidental deaths in the elderly. Although treatment is available, diagnosis poses a significant problem with diverse causes and symptoms requiring advanced technology to assist in the detection/analysis. Current technology is limited to single-function, difficult-to-operate, non- interpretative products, which are neither comprehensive nor time-efficient. SEVE will automate diagnostic and localizing tests that are well known in the literature, but are often discounted, not performed correctly or not performed at all due to practicality, and lack of standardization and training. Recently, Ph. I work was completed where we developed a working prototype and demonstrated the value of SEVE in a small subject cohort and assessed user friendliness. For Ph. II, we anticipate developing several novel protocols, adding additional testing and functionality, engineering modifications, enhancing software for diagnostic protocols, interpretation, integrative analysis for decision support, and evaluating SEVE's performance with a subject population at the PI's clinic and 2 independent sites.