Exercise Intervention on Cortisol Secretion and Cardiovascular Disease Risk

描述(由申请人提供)：儿童和青少年肥胖率正在以惊人的速度增长。有证据表明，儿童肥胖与成年后发病率和死亡率的增加有关。美国人口已经转向久坐不动的生活方式，这进一步加剧了肥胖症的流行。中枢脂肪沉积已成为肥胖对健康危害的重要预测指标。皮质醇水平升高会导致代谢综合征特征的中枢脂肪沉积。肥胖成年人的下丘脑-垂体-肾上腺轴的功能已经被研究过。皮质醇与青少年心血管疾病风险分布之间的相关性还没有得到很好的证实，特别是与肥胖有关。美洲原住民患肥胖症和心血管疾病的几率更高。在这项研究中，我们将确定居住在阿纳达科的青少年唾液皮质醇的相关性，阿纳达科是俄克拉荷马州西南部七个部落的中心位置。我们还将检查为期12周的标准化运动训练计划对高危青少年唾液皮质醇和心血管疾病风险的影响。

DESCRIPTION (provided by applicant): The prevalence of obesity in children and adolescents is increasing at an alarming rate. Evidence exists that childhood obesity is associated with an increased risk of morbidity and mortality through adulthood. The US population has moved towards a sedentary life style, which has further exacerbated the obesity epidemic. Central body fat deposition has emerged as an important predictor of the health hazards of obesity. Increased levels of cortisol cause central fat deposition characteristic of the metabolic syndrome. The function of the hypothalamic-pituitary-adrenal axis in obesity has been studied in adults. The correlation between cortisol and the cardiovascular disease risk profile in adolescents is not well established, particularly as related to obesity. Native Americans have a higher incidence of obesity and cardiovascular disease. In this study, we will determine correlates of salivary cortisol in adolescents living in Anadarko, a central location of the Seven Tribes of Southwest Oklahoma. We will also examine the effect of a 12-week standardized exercise training program on salivary cortisol and the cardiovascular disease risk profile in at risk adolescents.