Prenatal set point for adult blood pressure

成人血压的产前设定点

• 批准号: 6595222
• 负责人: JOB J. FABER
• 金额: $ 31.28万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-06-01 至 2007-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6595222
• 关键词: angiotensin II; blood chemistry; blood pressure; cardiac output; embryo /fetus; embryo /fetus disorder; embryo /fetus surgery; glomerular filtration rate; heart; hypertension; kidney; mature animal; morphology; newborn animals; pathologic process; pulmonary hypertension; radioimmunoassay; renin; renin angiotensin system; sheep; ventricular hypertrophy

Late gestation fetal sheep will be treated to create systemic and pulmonary arterial hypertensions. One group will have high circulating angiotensin-II levels. There will be two normotensive control groups, one with normal and one with low angiotensin-II. The animals will be studied as fetuses, as newborns and as young adults. Circulatory measurements will include arterial pressures, right and left atrial pressures and cardiac outputs. We will also make plasma renin activity/renal ar6terial pressure response curves and measurements of glomerular filtration rates. Analytical measurements will include plasma renin activities, circulating angiotensin-II levels, catecholamines, plasma protein and blood hemoglobin concentrations, blood gases, osmolalities and electrolytes. Coronary pressure-flow relations will be determined under anesthesia with and without chemical dilation by means of adenosine infusions to determine coronary reserve. The animals will be killed for structural studies of heart and kidney. It is anticipated that prenatal hypertensions will produce lasting circulatory abnormalities later in life.

将对妊娠晚期胎羊进行处理，以产生全身和肺动脉高血压。一组将具有高循环血管紧张素-II水平。将有两个血压正常的对照组，一个正常，一个低血管紧张素-II。动物将作为胎仔、新生儿和年轻成年动物进行研究。循环测量将包括动脉压、左右心房压和心输出量。我们还将绘制血浆肾素活性/肾动脉压响应曲线并测量肾小球滤过率。分析测量将包括血浆肾素活性、循环血管紧张素II水平、儿茶酚胺、血浆蛋白和血液血红蛋白浓度、血气、渗透压和电解质。将在麻醉状态下通过腺苷输注进行化学扩张和未进行化学扩张来确定冠状动脉压力-流量关系，以确定冠状动脉储备。将处死动物进行心脏和肾脏的结构研究。据估计，产前高血压将在以后的生活中产生持久的循环异常。