The Dynamics of Hippocampal-parietal Correlations

提供的空间） 空间感知是一个高度复杂的层次问题。大脑的几个部分直接 参与不同类型空间参考系的空间处理和编码。这些区域工作 一起产生一个完整的，一致的环境表示。本研究的目的是 更好地理解自我中心（相对于动物的）之间的关系和可能的相互作用 顶叶皮层中的空间参考框架和 海马体，并在这两个区域的活动中寻找标记之间过渡的“签名” 另一区域中的替代空间帧。我计划同时从大量的 在不同形状的跑道上跑步的大鼠的顶叶和海马神经元，研究 这些区域的放电活动及其对轨道几何形状变化的反应。我打算测试一下 顶叶皮层的放电活动与CA1的放电活动相关。此外，我将工作 掌握和扩展了一套基于自适应滤波算法的软件工具。 弗兰克的实验室，它可以准确描述神经尖峰活动的真实的时间动态。

spaceprovided) Spatial perception is a highly complex hierarchical problem. There are several parts of the brain that directly participate in spatial processing and code for different kinds of spatial reference frames. These regions work together to produce a complete, consistent representation of the environment. The goal of this study is to better understand the relationships and possible interactions between the egocentric (relative to animal's body) spatial reference frame in the parietal cortex and the allocentric (relative to the world) frame in the hippocampus, and to look for "signatures" in the activity of either region that mark transitions between alternative spatial frames in the other region. I plan to collect data simultaneously from large numbers of parietal and hippocampal neurons of a rat running on a track with variable shape to study the properties of firing activity in these regions and their responses to the changing geometry of the track. I plan to test the hypothesis that firing activity in parietal cortex is correlated with firing activity in CA1. In addition, I will work on mastering and extending a set of software tools based on the adaptive filtering algorithm used in Dr. Frank's laboratory, which allows accurate description of real time dynamics of neural spiking activity.