Research Program and Administrative Center

A.对中心的总体描述 A.1结构和重点。作为对RFA DE-08-008的回应，美国印第安人/阿拉斯加土著计划 (AIANP)在华盛顿大学医学院(SOM)和牙科医学院(SODM) 科罗拉多州丹佛健康科学中心(UCDHSC)与我们的合作伙伴，位于 Buffalo SODM，提议建立一个减少口腔健康差异的研究中心(CRRDOH)，资金来源为 NIDCR作为合作研究中心(U54)。与我们有合作的其他高等教育机构 已建立的关系专注于招募学生从事口腔健康差异研究的潜在职业 包括路易斯堡学院，该学院的任务是为美国印第安人和阿拉斯加(AI/AN)学生提供服务；以及 几所部落学院，包括奥格拉拉南达科他州Rosebud保留地上的Sinte Gleska大学 松岭的拉科塔学院和纳瓦霍民族的用餐学院。松岭卫生局 政府和松岭印度卫生服务(IHS)单位与我们合作开展研究 组件1(RC1)。IHS的阿尔伯克基地区服务单位将参加RC2；塔里希纳服务 单位(俄克拉荷马州/乔克托民族)也可以参加。纳瓦霍民族餐饮教育部门和 Head Start预计将参与RC3。科罗拉多州公共卫生学院倡议，其中包括 由科罗拉多大学、科罗拉多州立大学和北方大学联合提供的课程 科罗拉多州，也将与我们合作，特别是在开发新的培训和职业机会方面。 注：本申请中使用的缩写请参见附录RPAC-1。 尽管其他群体存在差异，但人工智能/ANS的糟糕健康状况在许多方面都是无与伦比的。 预期寿命几乎比一般人少6岁，发病率和死亡率都更高。 治疗范围广泛的疾病和健康问题，包括糖尿病、结核病、肺炎和某些形式 1口腔感染(龋齿和牙周病)及其后遗症，如牙髓缺乏症 在人工智能/人工智能人群中显著高于普通人群2随着证据的建立证实了两者之间的联系 在口腔健康状况和全身健康状况之间，例如牙周病和糖尿病， 这些差距的严重性加剧了这种差距。 这里提议的中心将被称为本地人口腔健康研究中心(CNOHR)，并将 重点关注AI/AN人群中的口腔健康差异。“美洲印第安人和阿拉斯加原住民”或 在本申请中，“AI/An”将指那些将其起源追溯到大陆土著人民的人。 美国；“Native”是AI/an的同义词。缩写词汇表见附录RPAC-1。)首字母 研究计划将解决两种最常见的口腔感染，龋齿和牙周病，并将 在显著的共病模式或口腔-全身连接的背景下这样做。特别关注 将关注影响和构成口腔健康风险因素的行为和社会因素 寿命。确保制定将被接受和推广的对文化敏感的干预措施 被邀请参加干预研究的人工智能/人工智能社区、部落和社区 过去和今后都将继续参与这些干预措施的规划和传播。 除了在现有研究基础上发展和进行跨学科干预 将导致医疗保健政策、实践以及最终口腔健康变化的研究，CNOHR将 开发培训机会，目标是培养一批自给自足的学者，他们是 准备解决这里确定的差距。CNOHR还提供经验和承诺 需要发展持久的社区关系和支持，有时是工作所必需的 与部落和其他人工智能/人工智能社区/组织进行研究的充满政治色彩的背景。最后，CNOHR将 作为国家资源，鼓励和支持合作研究、研究培训、信息 传播，并向更大的人工智能/口腔健康社区提供技术援助。通过扩展以下方面的机会 研究开发和对其他健康差距调查人员的支持，CNOHR将增强 致力于改善美国原住民口腔健康的研究。

A. DESCRIPTION OF THE CENTER OVERALL A.1 STRUCTURE AND FOCUS. In response to RFA DE-08-008, the American Indian/Alaska Native Programs (AIANP) within the School of Medicine (SOM) and the School of Dental Medicine (SODM) at the University of Colorado at Denver and Health Sciences Center (UCDHSC), with our collaborating partner, the University at Buffalo SODM, propose a Center for Research to Reduce Disparities in Oral Health (CRRDOH), to be funded by the NIDCR as a Cooperative Research Center (U54). Other higher education institutions with which we have established relationships focused on recruiting students for potential careers in oral health disparities research include Fort Lewis College, which has a mandate to serve American Indian and Alaska (AI/AN) students; and several tribal colleges, including Sinte Gleska University on the Rosebud Reservation in South Dakota, Oglala Lakota College at Pine Ridge, and Dine College of the Navajo Nation. The Pine Ridge Department of Health Administration and the Pine Ridge Indian Health Service (IHS) Unit have worked with us to develop Research Component 1 (RC1). The Albuquerque Area Service Unit of the IHS will participate in RC2; the Talihina Service Unit (Oklahoma/Choctaw Nation) may also take part. The Navajo Nation Departments of Dine Education and Head Start are expected to participate in RC3. The Colorado School of Public Health Initiative, which includes programs offered jointly by the University of Colorado, Colorado State University, and the University of Northern Colorado, will work with us as well, particularly in the development of new training and career opportunities. Note: Please see Appendix RPAC-1 for abbreviations used in this application. Although disparities exist for other groups, the poor health status of AI/ANs is unparalleled in many respects. Life expectancy is almost 6 years less than for the general population and both morbidity and mortality are higher for a broad range of diseases and health problems, including diabetes, tuberculosis, pneumonia, and some forms of cancer.1 Oral infections (caries and periodontal disease) and their sequelae, such as edentulism, also are significantly higher among AI/ANs than among the general population.2 As evidence builds to substantiate a link between oral health status and systemic health conditions¿e.g., periodontal disease and diabetes, the seriousness of these disparities is compounded. The center proposed here will be known as the Center for Native Oral Health Research (CNOHR) and will focus on oral health disparities among AI/AN populations. (The term "American Indian and Alaska Native" or "AI/AN" will refer in this application to those who trace their origins to the indigenous peoples of the continental US; "Native" is used synonymously with AI/AN. See Appendix RPAC-1 for glossary of abbreviations.) The initial program of research will address the 2 most common oral infections, caries and periodontal disease, and will do so within the context of salient patterns of comorbidities, or oral-systemic connections. Special attention will be given to behavioral and social factors that influence and constitute risk factors for oral health across the lifespan. To ensure the development of culturally sensitive interventions that will be accepted and promoted by AI/AN communities, tribes and communities that have been invited to participate in intervention studies have been, and will continue to be, engaged in planning and dissemination of those interventions. In addition to building on the current research base to develop and conduct interdisciplinary intervention research that will lead to changes in health care policies, practices, and ultimately oral health, CNOHR will develop training opportunities, with the goal of cultivating a self-sustaining critical mass of scholars who are prepared to address the disparities identified here. CNOHR also offers the experience and commitment necessary to develop the enduring community relations and support essential for working in the sometimes politically charged context of research with tribal and other AI/AN communities/organizations. Finally, CNOHR will serve as a national resource to encourage and support collaborative research, research training, information dissemination, and technical assistance to the larger AI/AN oral health community. By extending opportunities for research development and support to other health disparities investigators, CNOHR will enhance capacity for research dedicated to improving the oral health of America's First Peoples.