Biostatistics and Bioinformatics Shared Resource

生物统计学和生物信息学共享资源 项目摘要/摘要 生物统计和生物信息学共享资源(Biostats SR)是CASE的重要资产 综合癌症中心(Case CCC)成员的研究，由科学计划的广度说明 参与并反映在使用这一SR的大量调查人员中。仅去年一年就有140多人 来自该中心所有7个项目的调查人员，其中53%是Case CCC成员，在 超过300个项目，总计6500个小时。Biostats SR的主要焦点是提供统计数据 支持提案/临床方案制定、试点研究或其他由NIH资助的同行评审研究。在……里面 此外，此SR使用标准按存储容量使用计费模型和协作拨款工作模型提供数据分析 包括大而密集的基因组数据集的服务。Biostats SR还利用来自 计算生物学研究所(ICB)提供和加强信息学支持。Biostats SR带来 结合生物统计学、生物信息学、信息学、临床试验方面的专业知识和智力资源， 流行病学和统计计算。Biostats SR使用标准提供数据分析服务 按存储容量使用计费和协作拨款工作模式。Biostats SR生物统计学家为议定书审查和 监测委员会(PRMC)，协助审查新研究和监测正在进行的研究。 生物统计和生物信息学共享资源的具体目标是： 1)为CASE CCC成员设计提供生物统计、生物信息学、研究信息学支持； 研究研究的规划、实施、分析和报告。 2)通过评审方案，确保正确设计、实施和监控案例CCC研究 和建议，并为正在进行的临床研究的质量控制、数据和安全监测作出贡献。 3)利用OnCore临床试验管理数据库提供和协调信息支持 和其他安全的研究数据库，并作为翻译信息学在案件中的礼宾 Ccc。 在最近的一次审查中，Biostats SR被评为“杰出的优点”。在本供资周期(2012-2016年)， Biostats SR为298名注册用户提供服务，其中134名(45%)是Case CCC成员， 代表Case CCC的所有7个项目。 增值服务(研究问题和实验设计的制定、功率和样本量 计算、数据质量评估和控制、统计分析、结果解释以及 BIOSTATS SR提供的建议书/手稿撰写和支持)通过成功的 Biostats SR人员对中心研究生产力的贡献。支持的初始协作 该中心经常通过合作研究资助带来成功的新资金，Biostats SR人员对此进行了研究 担任联合调查员。Biostats SR服务对于提高该中心的科学质量至关重要。

BIOSTATISTICS AND BIOINFORMATICS SHARED RESOURCE PROJECT SUMMARY/ABSTRACT The Biostatistics and Bioinformatics Shared Resource (Biostats SR) is an essential asset to Case Comprehensive Cancer Center (Case CCC) members' research, illustrated by the breadth of scientific program involvement and reflected in the large number of investigators who use this SR. Last year alone over 140 investigators, 53% of whom were Case CCC members, from all 7 of the Center's Programs, used the SR on over 300 projects, for a combined 6,500 hours. The primary focus of the Biostats SR is to provide statistical support for proposal/clinical protocol development, pilot studies, or other NIH-funded peer-reviewed studies. In addition, using a standard chargeback model and collaborative grant effort model, this SR provides data analysis services including big and dense omic datasets. The Biostats SR also leverages institutional resources from the Institute for Computational Biology (ICB) to provide and strengthen informatics support. The Biostats SR brings together expertise and intellectual resources in biostatistics, bioinformatics, informatics, clinical trials, epidemiology, and statistical computing. The Biostats SR provides data analysis services using standard chargeback and collaborative grant effort models. Biostats SR biostatisticians serve on the Protocol Review and Monitoring Committee (PRMC), assisting with review of new studies and monitoring of ongoing studies. Specific aims of the Biostatistics & Bioinformatics Shared Resource are to: 1) Provide biostatistical, bioinformatics, and research informatics support to Case CCC members for design, planning, conduct, analysis, and reporting of research studies. 2) Ensure that Case CCC studies are designed, conducted, and monitored properly by reviewing protocols and proposals, and contribute to quality control and data and safety monitoring of ongoing clinical studies. 3) Provide and coordinate informatics support by using the OnCore clinical trials management database and other secure research databases, and serve as a concierge for translational informatics in the Case CCC. At last review, the Biostats SR was rated “Outstanding Merit”. Throughout the current funding cycle (2012-2016), the Biostats SR provided services to 298 registered users, 134 (45%) of whom are Case CCC members, representing all 7 of the Case CCC programs. The value-added services (formulation of research questions and experimental design, power and sample size calculations, data quality assessment and control, statistical analysis, results interpretation, as well as proposal/manuscript writing and support) provided by the Biostats SR is demonstrated by the successful contribution of Biostats SR personnel to the Center’s research productivity. Initial collaborations supported by the Center often lead to successful new funding via collaborative research grants on which Biostats SR personnel serve as co-investigators. Biostats SR services are essential in enhancing the quality of science in the Center.