PROTECTION AGAINST RESPIRATORY PATHOGENS WITH OLIGONUCLEOTIDE CPG

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者的研究机构。 目的：测试寡核苷酸CpG是否可以刺激呼吸道中的先天免疫机制，从而保护恒河猴免受麻疹病毒的急性呼吸道粘膜攻击。第二个目标是确定先天免疫的CpG引发是否可以增强呼吸道激发后对麻疹病毒的适应性免疫应答。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: To test whether an oligonucleotide CpG can stimulate innate immune mechanisms in the respiratory tract that can protect against an acute respiratory mucosal challenge with measles virus in the rhesus monkey. A secondary objective will be to determine whether CpG priming of innate immunity can augment the adaptive immune response to measles virus following a respiratory challenge.