Milwaukee Clinical Site Hub

描述（由申请人提供）：Froedtert Memorial Lutheran Hospital (FMLH) 急诊科与威斯康星医学院 (MCW) 和威斯康星儿童医院合作提交此申请，以考虑成为 NINDS 紧急治疗试验网络 (NETT) (RFA-NS-06-009) 的临床中心中心 (CSH)，即密尔沃基临床中心中心（MCSH）。选定的 NETT 网络协议的实施将利用密尔沃基县紧急医疗服务 (EMS) 系统的屡获殊荣的模型以及位于 FMLH 成人急诊部的全国认可的成人和儿童创伤中心以及位于 MCW 园区的毗邻威斯康星州儿童医院 (CHW) 儿科急诊部。 Froedtert 纪念路德医院、Froedtert-MCW 中风和神经血管中心、威斯康星州儿童医院和密尔沃基县 EMS 系统将作为密尔沃基中心的基础。该地区 15 家附属护理人员接收社区医院中的 8 家将作为临床中心，支持实时患者评估和招募，并促进研究成果的传播。这些医院是密尔沃基急诊医学研究联盟 (MEMRC) 的成员，该联盟是一个经验丰富且经过验证的研究协会，以其支持院内和院外研究的长期基础设施而著称。密尔沃基中心将利用其庞大的现有研究基础设施，以经济高效的方式实现 NTT 的目标，提供临床领导、研究支持和当地神经学专业知识；协调 IRB 活动和人类受试者保护；输入数据、管理合同并监督培训活动。主要研究者和关键人员致力于与 NTT 网络积极合作，并在社区卫生保健提供者中传播集体活动的成果。密尔沃基中心的目标是： 1) 利用我们现有的基础设施、已建立的合作以及在 EMS 和医院环境中进行临床研究的经验（包括紧急情况下知情同意的例外情况）来进行选定的 NTT 临床试验，以提高神经系统紧急情况下临床研究的效率； 2）协调多个急诊医学科室和医院的参与，加快神经病学研究的患者招募； 3) 吸引来自 MCW 和参与医院的广泛调查人员； 4) 最大限度地发挥我们的成功经验和能力来招募和留住广泛的合格受试者； 5) 与其他NETT中心合作，促进研究成果的转移； 6) 与网络成员协调开发和测试创新的远程医疗方法，涉及急诊科神经系统疾病护理的异地专家。

DESCRIPTION (provided by applicant): The Department of Emergency Medicine of Froedtert Memorial Lutheran Hospital (FMLH) in collaboration with the Medical College of Wisconsin (MCW), and the Children's Hospital of Wisconsin are submitting this application for consideration to become a Clinical Site Hub (CSH) of the NINDS Emergencies Treatment Trials Network (NETT)(RFA-NS-06-009), to be known as the Milwaukee Clinical Site Hub (MCSH). Implementation of the selected NETT Network protocols will exploit the award-winning models of the Milwaukee County Emergency Medical Services (EMS) System and the nationally recognized Adult and Pediatric Trauma Centers housed at FMLH Adult Emergency Department and the adjoining Children's Hospital of Wisconsin (CHW) Pediatric Emergency Department, located on the MCW campus. Froedtert Memorial Lutheran Hospital, the Froedtert-MCW Stroke and Neurovascular Center, the Children's Hospital of Wisconsin, and the Milwaukee County EMS System will serve as the foundation of the Milwaukee Hub. Eight of the area's 15 affiliated paramedic-receiving community hospitals will serve as clinical spokes to support patient assessment and recruitment in real time and facilitate the dissemination of research results. These hospitals are members of the Milwaukee Emergency Medicine Research Consortium (MEMRC), an experienced and proven research association, distinguished by its long-standing infrastructure to support in- hospital and out-of-hospital research. The Milwaukee HUB will capitalize on its enormous existing research infrastructure to cost-effectively achieve the goals of the NETT to provide clinical leadership, research support, and local neurological expertise; coordinate IRB activities and human subjects protections; enter data, manage contracts, and oversee training activities. The principal investigator and key personnel are committed to actively partnering with the NETT Network and to disseminating the outcomes of the collective activities among community health care providers. The Milwaukee HUB aims to: 1) Leverage our existing infrastructure, established collaborations, and experience in conducting clinical research in the EMS and hospital settings (including exception to informed consent under emergency circumstances) to perform selected NETT clinical trials to enhance the efficient conduct of clinical research in neurological emergencies; 2) Orchestrate the participation of multiple emergency medicine departments and hospitals to expedite patient recruitment in neurological studies; 3) Engage a wide spectrum of investigators from MCW and participating hospitals; 4) Maximize our successful experience and capacity to recruit and retain a broad range of qualified subjects; 5) Cooperate with other NETT Hubs in facilitating the transfer of research; and 6) Coordinate with Network members in developing and testing innovative telemedicine methods involving off-site specialists in the care of neurological disorders in the emergency department.