Animal Core

该应用的主要目标是开发新的疫苗、诊断和治疗方法 A-C类优先级特工需要动物模型来提高我们对宿主病原体的理解 测试新开发的产品。由于许多病原体需要BSL-3 封闭，最先进的BSL-3动物园将是至关重要的，在实现我们的研究目标。因此，我们有 为了满足NBC科学家当前和不断扩大的需求，我们建立了一个动物核心。的 动物中心的目标是：1）提供高质量的BSL-3动物设施; 2）建议和培训 A-C类优先药物的动物模型研究者;以及3）鼓励 NBC成员。 NBC动物中心由2号区域内四个地点的BSL-3动物园组成， 种类繁多的动物将进行涉及啮齿动物、兔子和鸟类的小动物研究 在PHRI，纽瓦克，NJ或沃兹沃斯中心，奥尔巴尼，NY的两个BSL-3动物园之一。家畜研究 人畜共患病病原体将位于Plum Island Animal Disease Center，Plum Island，NY。非人 灵长类动物研究将在加勒比灵长类动物研究中心（波多黎各）进行。之多样 这四个设施中的动物物种是必不可少的，以解决类别的多样性 A-C优先级特工此外，这些设施的各种科学专门知识将提供出色的培训 和NBC研究界的合作机会。

A primary goal of this application is the development of new vaccines, diagnostics, and therapeutics for category A-C priority agents. Animal models will be needed to improve our understanding of the hostpathogen relationship and to test newly developed products. Since many of the pathogens require BSL-3 containment, state-of-the-art BSL-3 vivaria will be critical in reaching our research goals. Thus, we have established an Animal Core in order to the meet the current and expanding needs of NBC scientists. The objectives of the Animal Core are: 1) to provide high quality BSL-3 animal facilities; 2) to advise and train investigators in animal models for category A-C priority agents; and 3) to encourage collaborations between NBC members. The NBC Animal Core consists of BSL-3 vivaria at four sites within region 2 and provides facilities for a wide variety of animal species. Small animal studies involving rodents, rabbits, and birds will be performed at one of two BSL-3 vivaria at PHRI, Newark, NJ or Wadsworth Center, Albany, NY. Studies in livestock on zoonotic pathogens will be located at the Plum Island Animal Disease Center, Plum Island, NY. Non-human primate studies will be conducted at the Caribbean Primate Research Center, Puerto Rico. The diversity of animal species available at these four facilities is essential in order to address the diversity of the category A-C priority agents. In addition, the diverse scientific expertise at these facilities will provide excellent training and collaborative opportunities for the NBC research community.