Next generation wireless neural interfaces for chronic and acute applications

拟议的BRP的目标是为无线神经接口技术奠定基础，使其成为可传播给神经科学和临床研究社区的交钥匙技术。在24个月内，该项目将产生初始设计和性能数据，作为第一代无线接口的核心，用于研究和急性和慢性临床使用。此外，还将寻求36个月的资金，以将这些初始设备转化为强大的工具，用于准备更晚的FDA 510 k应用程序。为了实现这一目标，我们将)改进我们最近开发和演示的无线神经接口技术，专注于在真实环境中制造更小且故障安全的VLSI信号处理和遥测，2)开发下一代系统集成和电子封装技术，3)开发用户友好的软件界面和外部电子系统，4)生成更长的无线刺激和记录系统的活体数据，以验证集成系统。这项更高的跨学科研究将与犹他大学、斯坦福大学、弗劳恩霍夫可靠性研究所和微集成实验室犹他州和瑞普尔的微纳系统标准集成技术Vl51和神经生理学方面的专业知识合作进行。

The goal of the proposed BRP is to lay the foundation to make wireless neural interface technology a turnkey technology that can be disseminated to the neuroscience and clinical research communities. Within 24 months this project will generate initial de ices and performance data as a nucleus for a first generation of wireless interfaces for research and acute and chronic clinical use. Further > 36 months of funding will be sought separately to render these init al devices into robust tools that can be used in the preparation of a later FDA 510 k application. In order 0 achieve this goal, we will) refine our recently developed and demonstrated wireless neural interface technology, focusing on making smaller and failsafe VLSI signal processing and telemetry in real w rid environments, 2) develop next generation system integration and electronic packaging technologies, 3) develop user-friendly software interfaces and external electronic systems, 4) generate longer in vivo data of wireless stimulation and recording systems to validate the integrated systems. This higher interdisciplinary research will be carried out in partnership of expertise in micro and nano systems Standard Integration Technology, Vl51, and neurophysiology at the University of Utah, Stanford University, the Fraunhofer Institute for Reliability and Micro integration laboratory Utah and Ripple.