A Trial to Test the Efficacy of a Tailored Intensive Smoking Cessation Interventi

描述(由申请人提供)：2006年美国国立卫生研究院关于烟草使用的科学会议声明：预防、戒烟和控制强调需要“为不同的人群量身定制干预措施，因为仿制药可能不适合每个人”，并确定戒烟活动在烟草使用率高和其他并存人群中的有效性。他们将艾滋病毒感染者社区确定为这些努力的高度优先目标。在美国，超过一半的艾滋病病毒携带者(PWHs)吸烟，这一群体的心脏事件和烟草相关癌症的发病率正在以惊人的速度上升。艾滋病毒感染者群体的心理社会状况表明，实现高戒毒率将是一项巨大的挑战，其特点是精神疾病共患率高，吸毒和酗酒，社会支持水平低。这项建议的主要目标是(1)根据研究人员在初步研究中收集的大量行为数据，开发和试点针对PWHs的定制、多成分、强化戒烟干预措施，以及(2)对PWH吸烟者进行随机对照研究，以确定定制干预措施在实现三个月、点流行戒烟方面的效果。这项拟议研究的长期目标是扩大PWHs戒烟的现有知识基础，并开发适合全国PWHs的强化戒烟计划课程。与公共卫生相关：吸烟的流行加上艾滋病毒携带者(PWHs)的老龄化人口及其相关的共病，是一种新的公共卫生危机。威斯康星医院的吸烟者几乎没有为他们的需求量身定做的戒烟资源，他们的护理人员几乎没有研究来建立基于证据的方法来实现戒烟。这项提案如果获得资金，将开始解决这些关键需求。

DESCRIPTION (provided by applicant): The 2006 NIH State-of-the-Science Conference Statement on Tobacco Use: Prevention, Cessation, and Control emphasized the need to "tailor interventions for different populations because generic treatments may not be appropriate for everyone," and to determine the effectiveness of cessation activities in populations with high rates of tobacco use and other comorbidities. They identified the HIV-infected community as a high priority target for these efforts. More than half of persons with HIV (PWHs) in the US smoke cigarettes, and incidence rates of cardiac events and tobacco related cancers are rising in this group at an alarming rate. The psychosocial profile of the HIV-infected community, characterized by high rates of psychiatric comorbidity, drug and alcohol use, and low levels of social support, suggests that achieving high cessation rates will be a great challenge. The main goals of this proposal are to (1) develop and pilot a tailored, multicomponent, intensive smoking cessation intervention for PWHs based upon a body of behavioral data that the investigators have collected in a preliminary study, and (2) perform a randomized, controlled study in PWH smokers to determine the efficacy of the tailored intervention in achieving three month, point-prevalence abstinence from tobacco use. The long term objectives of the proposed study are to expand the available knowledge base on smoking cessation in PWHs, and to develop an intensive smoking cessation program curriculum appropriate for PWHs throughout the nation. PUBLIC HEALTH RELEVANCE: The epidemic of cigarette smoking superimposed upon an aging population of persons living with HIV (PWHs) and its associated comorbidities represents an emerging public health crisis. PWH smokers have few, if any, smoking cessation resources available to them that are tailored to their needs, and their care providers have virtually no studies upon which to build an evidence-based approach to achieving abstinence. This proposal, if funded, will begin to address these critical needs.