Genotype-Environment variation in heavy metal tolerance

自然过程和人类活动都可能导致环境毒素。毒性的严重程度各不相同 既对毒素敏感，又有特殊遗传背景的易感性。进化论 毒性的后果取决于基因变异和不同暴露之间的相互作用 环境。理解这些相互作用的理想模型系统是一个自然存在的 对自然产生的毒素的易感性发生变化，如对重金属的耐受性 拟南芥是拟南芥的近亲。在这个系统中，接触重金属只发生在 环境是有限的，而宽容是有一定代价的，所以宽容并不是所有人都喜欢的 各就各位。我将通过高通量基因分型来研究赖拉塔耐重金属的遗传变异。 来自不同土壤类型、重金属浓度不同的生态型。了解自然变异 在重金属耐受性方面，无论存在还是不存在暴露，都对理解 对赋予耐受性的基因的进化限制，阐明耐受性的极限，并确定 如何在农业和环境健康的背景下提高耐受性。

Both natural processes and human activities can result in environmental toxins. The severity of toxicity varies with both expsoure to toxins and the susceptibility of particular genetic backgrounds. The evolutionary consequences of toxicity hinge on the interaction between genotypic variation and different exposure environments. The ideal model system for understanding these interactions is one where there is naturally occurring variation in susceptibility to naturally occurring toxins, such as heavy metal tolerance in Arabidopsis lyrata, the nearest relative of A. thaliana. In this systemexposureto heavy metals only occurs in a limited set of environments, and tolerance has somefitness cost, so that tolerance is not favored in all places. I will study genetic variation in heavy metal tolerance in A. lyrata through high-throughput genotyping of ecotypes from different soil types differing in heavy metal concentrations. Understanding natural variation in heavy metal tolerance, both in the presence and absence of exposure, is important to understanding evolutionary constraints on genes conferring tolerance, elucidating limits on tolerance, and for determining how tolerance can be improved in agricultural and environmental health contexts.