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中文摘要
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生物统计学核心的目标是与SPORE研究人员和其他核心资源合作 科学家,以提高密歇根大学前列腺孢子进行的研究质量。 核心人员的选择是因为他们在生物统计学相关领域的专业知识, 因为他们对前列腺癌的经验和知识。 生物统计学核心人员将与四个拟议项目中的每一个合作。核心也将 与其他核心以及所有资助的开发奖励相互作用,因此,这个核心至关重要, 对孢子来说很重要。核心人员将在调查的所有阶段与调查人员互动, 研究,从研究问题的制定开始,通过实验设计阶段 数据收集阶段,到数据分析和解释,到编写报告和传播 结果生物统计学专业知识不可或缺的两个领域是实验设计和数据 分析.从这一建议中可以明显看出,核心人员在以下方面发挥了重要作用: 设计拟议的实验和规划数据分析。核心的具体目标是1) 协助研究者设计临床和实验室实验; 2)协助研究者进行分析 临床和实验室实验数据的解释和科学手稿的写作 将前列腺癌孢子结果传递给科学界;以及3)进行翻译 生物统计学研究,以开发与前列腺癌相关的方法。
英文摘要
The goal of the Biostatistics Core is to collaborate with SPORE investigators and other core resource scientists to enhance the quality of the research undertaken in the University of Michigan Prostate SPORE. The Core personnel have been chosen because of their expertise in relevant areas of Biostatistics and because of their experience and knowledge of prostate cancer. Biostatistics Core personnel will collaborate with every one of the four proposed projects. The Core will also nteract with the other cores and also with all funded development awards, and, thus, this core is crucially mportant to the SPORE. Personnel from the core will interact with the investigators in all stages of the research, beginning with the formulation of the research question, through the experimental design stage and data collection stage, to data analysis and interpretation, to the writing of reports and dissemination of results. Two areas where biostatistical expertise is indispensable are in experimental design and data analysis. It will be apparent from this proposal that Core personnel have played a significant role in designing the proposed experiments and in planning the data analysis. The Specific Aims of the Core are 1) assist investigators in the design of clinical and laboratory experiments; 2) assist investigators in the analysis and interpretation of data from clinical and laboratory experiments and in writing of scientific manuscripts relaying prostate cancer SPORE results to the scientific community; and 3) undertake translational biostatistics research to develop methodology relevant to prostate cancer.
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Bioinformatics and Biostatistics Core
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Statistical Methods for Cancer Biomarkers
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