Genetic and environmental factors in cancer

该项目包括两项肺癌研究和我与NIEHS姐妹研究的工作。第一个是在洛杉矶的非裔美国人和白种人中进行的肺癌遗传易感性的病例对照研究。我在南加州大学任教时进行了这项研究。在本研究中，我检测了大量与肺癌相关的遗传多态性。我正在与我以前在南加州大学的学生合作，分析异硫氰酸酯，GSTM 1多态性和肺癌风险，这是我在上海研究发现的后续研究。我们还在合作分析抗Hu抗体与小细胞肺癌的关系。 第二项研究是一个汇集项目，我将我的肺癌数据贡献给一个合作研究，汇集了许多肺癌研究，为研究基因-环境相互作用提供足够的力量。 我是这个集资项目的顾问委员会成员。 在其他乳腺癌研究中，我也是姐妹研究的合作者，参与了最初的概念。我是Clarice温伯格博士领导的团队的合作者，以增加队列中早发性乳腺癌姐妹篇的样本和暴露数据收集。本研究采用了一种新颖的四元设计。温伯格博士从科门基金会获得了该项目的外部资金。

This project includes two lung cancer studies and my work with the NIEHS sister study. The first is a case-control study of genetic susceptibility to lung cancer in African-Americans and Caucasians in Los Angeles. I conducted this study while a faculty member at the University of Southern California. I have examined a large number of genetic polymorphisms relevant to lung cancer in this study. I am collaborating with my former student from USC on an analysis of isothiocyanates, GSTM1 polymorphisms and lung cancer risk, a follow-up of my Shanghai study finding. We are also collaboration on an analysis of anti-Hu antibody in the relation to small cell lung cancer. A second study is a pooling project where I have contributed my lung cancer data to a collaborative study to pool across a number of lung cancer studies to provide sufficient power for studying gene-environment interactions. I serve on the advisory committee for this pooling project. In other breast cancer research, I am also a collaborator on the Sister Study having been involved in the initial concept. I am a collaborator with a team led by Dr. Clarice Weinberg to add sample and exposure data collection on sisters with early onset breast cancer of participants in the cohort. This study uses a novel quad design. Dr. Weinberg received external funding for this project from the Komen foundation.