GHRELIN LEVELS WITH ORAL VS PER TUBE MEALS AFTER RYGB

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 具体目标 1. 确定病态肥胖患者胃分裂对ghrelin释放的时间依赖性影响。 2. 确定在RYGB期间胃分裂和由此产生的胃底隔离是否会改变病态肥胖受试者在术后早期进食后的ghrelin分泌模式。 3. 确定胃底在调节血浆ghrelin水平昼夜变化中的潜在作用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Specific Aims 1. Determine the time-dependent impact of gastric division on ghrelin release in the morbidly obese patient. 2. Determine whether gastric division with resultant fundic isolation during RYGB would alter the pattern(s) of ghrelin secretion in the early post-operative period following feeding in morbidly obese subjects. 3. Determine the potential role of the fundus in mediating the diurnal variation in plasma ghrelin levels.