THE DURATION OF THERAPEUTIC EFFECT OF DEEP BRAIN STIMULATION PARKINSON'S

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 本研究旨在探讨双侧丘脑底核脑深部电刺激(DBS-STN)对帕金森病患者的治疗作用时间。我们观察到，与手术前相比，患者即使在停药、停刺激的情况下，运动功能也有改善。我们想进一步调查这种情况是否因为DBS-STN延缓了疾病的发展。然而，这也可能是由于DBS-STN的治疗作用持续时间极长。为了了解DBS-STN的治疗作用时间，我们希望在安全的环境中评估患者在4天内停止刺激和药物治疗的情况。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The study is being conducted to investigate the duration of therapeutic action of bilateral subthalamic nucleus deep brain stimulation (DBS-STN) in patients with Parkinson's Disease. We have observed that patients show improvement in motor function even off-medication, off-stimulation compared to function pre-operatively. We would like to further investigate whether this occurred because DBS-STN slowed the progression of disease. However, it also may be due to an extremely long duration of therapeutic action of DBS-STN. In order to understand the duration of therapeutic action of DBS-STN, we wish to evaluate patients off stimulation and medication over a period of 4 days in a safe environment.