THE DURATION OF THERAPEUTIC EFFECT OF DEEP BRAIN STIMULATION PARKINSON'S DISEASE

脑深部刺激帕金森病治疗效果的持续时间

• 批准号: 7375206
• 负责人: Helen Bronte-Stewart
• 金额: $ 0.27万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7375206
• 关键词: DURATION; THERAPEUTIC; EFFECT; DEEP; BRAIN

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The study is being conducted to investigate the duration of therapeutic action of bilateral subthalamic nucleus deep brain stimulation (DBS-STN) in patients with Parkinson's Disease. We have observed that patients show improvement in motor function even off-medication, off-stimulation compared to function pre-operatively. We would like to further investigate whether this occurred because DBS-STN slowed the progression of disease. However, it also may be due to an extremely long duration of therapeutic action of DBS-STN. In order to understand the duration of therapeutic action of DBS-STN, we wish to evaluate patients off stimulation and medication over a period of 4 days in a safe environment.

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。本研究旨在探讨双侧丘脑底核脑深部电刺激(DBS-STN)对帕金森病患者的治疗作用时间。我们观察到，与手术前相比，患者即使在停药、停刺激的情况下，运动功能也有改善。我们想进一步调查这种情况是否因为DBS-STN延缓了疾病的发展。然而，这也可能是由于DBS-STN的治疗作用持续时间极长。为了了解DBS-STN的治疗作用时间，我们希望在安全的环境中评估患者在4天内停止刺激和药物治疗的情况。