THE DURATION OF THERAPEUTIC EFFECT OF DEEP BRAIN STIMULATION PARKINSON'S DISEASE

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。本研究旨在研究双侧丘脑底核脑深部电刺激（DBS-100）对帕金森病患者的治疗作用持续时间。我们观察到，与术前功能相比，即使停止药物治疗、停止刺激，患者的运动功能也有所改善。我们想进一步研究这是否是因为DBS-BMPs减缓了疾病的进展。然而，这也可能是由于DBS-100治疗作用的持续时间非常长。为了了解DBS-100的治疗作用的持续时间，我们希望在安全的环境中评估患者在4天内的刺激和药物治疗。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The study is being conducted to investigate the duration of therapeutic action of bilateral subthalamic nucleus deep brain stimulation (DBS-STN) in patients with Parkinson's Disease. We have observed that patients show improvement in motor function even off-medication, off-stimulation compared to function pre-operatively. We would like to further investigate whether this occurred because DBS-STN slowed the progression of disease. However, it also may be due to an extremely long duration of therapeutic action of DBS-STN. In order to understand the duration of therapeutic action of DBS-STN, we wish to evaluate patients off stimulation and medication over a period of 4 days in a safe environment.