THE DURATION OF THERAPEUTIC EFFECT OF DEEP BRAIN STIMULATION PARKINSON'S DISEASE

脑深部刺激帕金森病治疗效果的持续时间

• 批准号: 7375206
• 负责人: Helen Bronte-Stewart
• 金额: $ 0.27万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7375206
• 关键词: DURATION; THERAPEUTIC; EFFECT; DEEP; BRAIN

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The study is being conducted to investigate the duration of therapeutic action of bilateral subthalamic nucleus deep brain stimulation (DBS-STN) in patients with Parkinson's Disease. We have observed that patients show improvement in motor function even off-medication, off-stimulation compared to function pre-operatively. We would like to further investigate whether this occurred because DBS-STN slowed the progression of disease. However, it also may be due to an extremely long duration of therapeutic action of DBS-STN. In order to understand the duration of therapeutic action of DBS-STN, we wish to evaluate patients off stimulation and medication over a period of 4 days in a safe environment.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。这项研究正在研究帕金森氏病患者中双侧下丘脑深脑刺激（DBS-STN）的治疗作用持续时间。我们已经观察到，与术前功能相比，患者甚至过时的刺激，刺激不足，运动功能也会提高。我们想进一步调查是否发生这种情况，因为DBS-STN减慢了疾病的进展。但是，这也可能是由于DBS-STN的治疗作用的持续时间非常长。为了了解DBS-STN治疗作用的持续时间，我们希望在安全环境中4天内评估患者的刺激和药物。