FASEB Conference on Protein Kinases

描述(由申请人提供)：信号转导领域的目标是识别和表征作为信号通路的一部分从一个分子到另一个分子的通信的生化和分子基础。在过去的30年里，这一知识极大地提高了人们对这些信息的传递如何调节与正常生长和发育相关的各种细胞过程的理解。不幸的是，这些途径也是通过各种机制进行不适当调控的目标，当这种情况发生时，可能会出现各种人类发育障碍和疾病。蛋白质的磷酸化结构修饰现在被公认为是调节信号过程的主要机制。在人类基因组中有500多种蛋白激酶具有调节蛋白质磷酸化的潜力，但相对较少的是被很好地描述的。在这些细胞中，许多现在已知在正常发育和疾病中具有重要功能。由于这些酶在各种生物过程和许多人类疾病中发挥着核心作用，而且蛋白激酶是治疗干预的潜在靶点，因此人们在确定信息传递的分子基础和受影响的生物过程方面做出了巨大的努力。对新的激酶及其功能的表征可能会揭示更多新的治疗靶点。在蛋白激酶和蛋白磷酸化领域，这是真正令人兴奋的时刻。因此，为了这一科学发现的继续进行，该领域的领先科学家之间进行信息和思想交流是至关重要的。 自1983年创办以来，FASE B关于“蛋白激酶和蛋白磷酸化”的夏季研究会议(每两年举行一次)一直是信号转导领域的卓越会议之一，为学术界和工业界的研究成果交流提供了一个主要场所。拟议中的会议的目标是继续这一令人兴奋和热情的科学交流的传统。

DESCRIPTION (provided by applicant): The goal of the signal transduction field is to identify and characterize the biochemical and molecular basis of communication from one molecule to another as part of a signaling pathway. Over the last 30 years, this knowledge has provided a vastly improved understanding of how transfer of this information regulates a variety of cellular processes associated with normal growth and development. Unfortunately, these pathways are also the targets of inappropriate regulation through an assortment of mechanisms, and when this occurs a variety of human developmental disorders and diseases can arise. The structural modification of proteins by phosphorylation is now well established to be a major mechanism of modulating signaling processes. There are over 500 protein kinases in the human genome with the potential to regulate protein phosphorylation, but relatively few are well characterized. Of those that are, many are now known to possess important functions in normal development and disease. Because of the central role these enzymes play in a variety of biological processes and in many human diseases, and because protein kinases are potential targets for therapeutic intervention, a tremendous effort has been made at determining the molecular basis for information transmission and the biological processes affected. The characterization of new kinases and their functions will likely reveal even more novel therapeutic targets. These are truly exciting times in the protein kinase and protein phosphorylation arena. Thus, it is critical that the exchange of information and ideas between the leading scientists in the field occur in order for this scientific discovery to proceed. Since its inception in 1983, the FASEB summer research conference on "Protein Kinases and Protein Phosphorylation" (held biennially) has consistently been one of the preeminent meetings in the field of signal transduction, providing a premier venue for the communication of research findings from both academia and industry. The goal of the proposed conference is to continue this tradition of exciting and enthusiastic scientific exchange.