Signal Transduction within the Nucleus Gordon Conference

描述（由申请人提供）：本申请为2007年3月25日至30日在美国Venura CA皇冠广场酒店举行的题为“细胞核内信号转导”的戈登研究会议寻求部分资金。我们于2005年2月举行了非常成功的首次会议，我们还寻求为2009年春季举行的第三次会议获得资金承诺。这次会议汇集了各种各样的研究人员专注于了解信号通路如何参与核过程的调节。无数的酶和大分子机器组成了复杂的解码装置，确保生物体在不断变化的环境中生存。这次会议的独特之处在于研究信号通路的研究人员与研究核功能的研究人员的工作已经融合在一起。我们在信号传导和核过程方面大大扩展了这个项目，远远超出了我们的首届会议，该会议专注于激动剂诱导的核脂质和碳水化合物代谢。这些课程包括核细胞质信号，核脂质信号，染色质结构和修饰，DNA损伤/修复途径，核组织和空间结构的作用，核膜的动力学，mRNA的剪接和输出。许多这些途径和过程都与疾病过程的病理生理学建立了良好的联系，强调了它们与改善人类健康的关系。例如，DNA修复途径与癌症生物学的关系，以及层板病与早衰的关系。我们期待这将是一次杰出而独特的会议，为杰出的研究人员提供交流的机会。所要求的资金对支持这次会议将是非常宝贵的。

DESCRIPTION (provided by applicant): This application seeks partial funding for the Gordon Research conference entitled "Signal Transduction within the Nucleus" to be held March 25-30, 2007 at the Crown Plaza Hotel, Venura CA, USA. Our highly successful inaugural meeting was held February, 2005 and we seek to also secure funding commitment for our third meeting to be held in Spring 2009. This conference brings together a wide variety of investigators focused on understanding how signaling pathways participate in the regulation of nuclear processes. Numerous enzymes and macromolecular machines contribute to the complex ensemble of decoding devices necessary to ensure an organism's survival in ever-changing environments. The uniqueness of this conference is the mixing of investigators studying signaling pathways with those studying nuclear function whose work has converged. We have significantly broadened this program with respect to both signaling and nuclear processes, well beyond our inaugural conference which focused on agonist-induced nuclear lipid and carbohydrate metabolism. This programs includes nucleo-cytoplasmic signaling, nuclear lipid signaling, chromatin structure and modifications, DNA damage/repair pathways, roles of nuclear organization and spatial architecture, dynamics of the nuclear envelope, and mRNA splicing and export. Many of these pathways and processes have well-established connections to the pathophysiology of disease processes, underscoring their relationship to improving human health. For example, the relationships of DNA repair pathways to cancer biology, and laminopathies to premature aging (progeria). We anticipate that this will be an outstanding and unique meeting that offers the opportunity of cross-fertilization among outstanding investigators. The requested funds will be invaluable to the support of this conference.