2008-2011Metals in Biology Gordon Research Conference and Associated Graduate Res

描述（由申请人提供）：摘要：本提案要求三年的部分支持，在生物学戈登研究会议（MIB GRC）及其后代，戈登凯南生物无机研究生研究研讨会（MIB GK-GRS），每年在文图拉，CA在1月下旬举行的金属。 金属离子在超过三分之一的酶中起着关键作用，并且参与许多重要的健康相关的生物合成途径，包括电化学能量到化学能量的转化，以及抗生素、DNA、神经递质、类固醇、白三烯和激素的生物合成。关于金属酶功能的分子水平细节出现在化学，生物学和物理学的界面上的几个互补的研究领域。 这些会议的广泛和长期目标是促进研究的高度跨学科领域的讨论和合作，并通过为他们提供自己的社区意识来培养我们社区的年轻成员，并允许我们领域的未来领导者出现。 该应用程序的意义在于，MIB GRC为生物无机化学前沿研究的讨论提供了主要论坛。 本次会议的具体目标是召集约27位代表生物学研究中金属离子关键领域的发言人，共有150名与会者参加为期五天的会议，会议在相对孤立的环境中进行。 该计划将有一个主题演讲和九个会议，广泛讨论质子耦合电子转移，铁硫簇作为电子传输剂和复杂多电子过程的催化剂的组装和演变，硫配体在促进金属酶功能，金属离子促进的0-0键形成和裂解，在氧化应激下形成的活性氧的检测和解毒，以及生物启发的催化。此外，两个晚上的海报会议将允许所有与会者对这些主题的讨论作出贡献。金属离子在超过三分之一的酶中起着关键作用，并参与许多重要的生物合成途径，包括电化学能量向化学能量的转化，以及抗生素、DNA、神经递质、类固醇、白三烯和激素的生物合成。 关于金属酶功能的分子水平细节出现在化学，生物学和物理学的界面上的几个互补的研究领域。 与MIB GRC会议相关的正式和非正式讨论对该领域的发展至关重要，并促进了这一高度跨学科研究领域的合作。

DESCRIPTION (provided by applicant): Abstract: This proposal requests three years of partial support for the Metals in Biology Gordon Research Conference (MIB GRC) and its descendent, the Gordon-Kenan Bioinorganic Graduate Research Seminar (MIB GK-GRS), to be held annually in Ventura, CA in late January. Metal ions play critical roles in over one third of all enzymes, and are involved in a number of important health related biosynthetic pathways including the conversion of electrochemical to chemical energy, and the biosynthesis of antibiotics, DNA, neurotransmitters, steroids, leukotrienes, and hormones. The molecular level details regarding metalloenzyme function emerge from several complementary lines of study, at the interface of chemistry, biology, and physics. The broad and long term goal of these conferences are to foster discussion and collaborations in a highly interdisciplinary area of research, and nurture the younger members of our community by providing them with their own sense of community, and allowing the future leaders of our field to emerge. The significance of this application is that the MIB GRC provides the principal forum for the discussion of research at the forefront of bioinorganic chemistry. The specific aims of this meeting will be to convene ~27 speakers that represent critical areas of metal ions in biology research with a total of 150 participants for a five day conference in a relatively isolated setting. The program will have a keynote address and nine sessions that broadly address current issues in proton-coupled electron transfer, the assembly and evolution of iron sulfur clusters as electron transport agents and catalysts for complex multi electron processes, the role played by sulfur ligands in promoting metalloenzyme function, metal ion-promoted 0-0 bond formation and cleavage, the detection and detoxification of reactive oxygen species formed under oxidative stress, and bioinspired catalysis. In addition, two evening poster sessions will permit all of the conferees to contribute to the discussion of these topics. Metal ions play critical roles in over one third of all enzymes, and are involved in a number of important biosynthetic pathways including the conversion of electrochemical to chemical energy, and the biosynthesis of antibiotics, DNA, neurotransmitters, steroids, leukotrienes, and hormones. The molecular level details regarding metalloenzyme function emerge from several complementary lines of study, at the interface of chemistry, biology, and physics. Both the formal and informal discussions associated with the MIB GRC meeting are critical to the advancement of the field, and fostering collaborations in this highly interdisciplinary area of research.