Pathology of the Laboratory Mouse

描述(申请人提供)：我们目前正处于一场遗传学革命之中，这场革命有望将“突破性”生物医学研究推向新的水平。这场革命在很大程度上依赖于对基因之间的关系及其对复杂生物系统和表型的影响的分析。研究人员必须越来越熟练地操纵和使用遗传模型来解决各种重要的生物学问题。实验室小鼠已成为人类和家畜疾病的首选动物模型，也是研究基本生物功能的首选模型。建立这种模型的有效性依赖于分子生物学家、遗传学家、病理学家和临床医生之间的相互作用，这些人都有重叠但不同的技能。对于MD病理学家来说尤其如此，因为大多数人都是作为内科医生接受培训的，他们很少或根本不了解物种间的可变性和/或相似性。同样，兽医病理学家虽然习惯于与许多物种合作，但他们几乎没有或根本没有人类病理学经验，而且往往很少或根本没有老鼠的病理学专业知识。转基因小鼠的生产和使用的升级创造了对具有小鼠病理学专业知识的个人的需求。由于拥有这种专业知识的病理学家的严重不足，文献中充斥着对突变基因表型效应的不完整和不准确的描述。为了帮助解决这个问题，我们建议在接下来的三年里，继续在每年的秋季开设“实验室小鼠的病理学”。杰克逊实验室将在第一年(2007年)主办研讨会，而康奈尔大学和普渡大学将在随后几年(2008年、2009年)主办研讨会。加上适中的费用，场外场地的目的是让学生更容易进入研讨会，并突出老鼠模型在翻译生物医学中的相关性。研讨会本身将包括为期8天的病理学和组织病理学强化板凳培训课程，以及讨论特定疾病领域和模式的教学课程。研讨会将容纳约20名参与者，他们将有机会与来自杰克逊实验室和其他领先机构的一群著名的老鼠病理学家和遗传学家互动。

DESCRIPTION (Provided by applicant): We are currently in the midst of a genetics revolution that promises to push "breakthrough" biomedical research to new levels. A large part of this revolution depends upon the analysis of the relationships between genes and their effects on complex biological systems and phenotypes. Investigators must become increasingly skilled in the manipulation and use of genetic models to address a variety of important biological questions. The laboratory mouse has become the premier animal model for human and domestic animal diseases as well as the model of choice for studying basic biological functions. Establishing the validity of such models depends on interaction between molecular biologists, geneticists, pathologists, and clinicians all of which have overlapping but distinct skills. This is especially trued for the MD pathologists since most are trained as physicians who have little to no appreciation of interspecies variability and/or similarity. Likewise, veterinary pathologists, although used to working with many species, have little or no human pathology experience and often little or no mouse pathology expertise. The escalation in the production and use of genetically engineered mice has created a demand for individuals with mouse pathology expertise. Due to this severe deficit in pathologists with such expertise, the literature is being flooded with incomplete and inaccurate descriptions of phenotypic effects of mutated genes. In order to help address this problem, we propose to continue offering "Pathology of the Laboratory Mouse", in the fall each year, for the next 3 years. The Jackson Laboratory will host the workshop in the first year (2007), whereas Cornell and Purdue Universities will host the workshop in subsequent years (2008, 2009). Coupled with modest fees, the offsite venues are intended to make the workshop more accessible to students and to highlight the relevance of mouse models in translational biomedicine. The workshop itself will consist of 8 days of intensive bench training sessions in pathology and histopathology as well as didactic sessions in which particular disease areas and models will be discussed. The Workshop will accommodate approximately 20 participants who will have an opportunity to interact with a group of prominent mouse pathologists and geneticists both from The Jackson Laboratory, and other leading institutions.