EFFECTS OF H2 BLOCKERS, PROTON PUMP INHIBITORS AND EZETIMIBE ON THYROXINE ABSORP

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 甲状腺激素替代疗法(LT4)用于治疗甲状腺功能减退患者。我们计划检测组胺2受体拮抗剂(H2 RAs)和质子泵抑制剂(PPI)对LT4吸收的影响。此外，在我们的临床经验中，依折麦布可能会干扰LT4的吸收。在我们的研究中，在基线水平，健康志愿者将被给予一剂LT4，并在8小时内接受连续的实验室测试，以检查血清甲状腺激素水平的上升。在6到8周的洗脱期后，这些志愿者将被给予为期一周的每日剂量的H2RA或PPI，或者单剂量的依折麦布。一次LT4剂量将在本周结束时再次注射，随后重复抽取血清甲状腺激素水平。我们将比较健康志愿者在服用LT4后在基线和治疗后的甲状腺激素浓度：a)为期一周的H2RA疗程，b)为期一周的PPI疗程，或c)同时服用剂量的依折麦布。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Thyroxine replacement therapy (LT4) is used to treat hypothyroid patients. We plan to examine the effects that histamine 2 receptor antagonists (H2RAs) and proton pump inhibitors (PPIs) each have on LT4 absorpition. Also, in our clinical experience, ezetimibe may interfere with LT4 absorption. in our study, at baseline, healthy volunteers will be given a dose of LT4 and undergo successive lab tests over 8 hours to examine the rise of serum thyroid hormone levels. After a washout period of six to eight weeks, these same volunteers will be given either daily doses of an H2RA or a PPI for one week or a single dose of ezetimibe. A single LT4 dose will be administered again at the end of the week, followed by repeat drawing of serum thyroid hormone levels. We will compare thyroid hormones concentrations achieved following LT4 administration to the healthy volunteer at baseline versus after therapy with: a) week long course of an H2RA, b) week long course of a PPI or c) simultaneously administered dose of ezetimibe.