SEQUENTIAL BREAST MILK IODINE CONCENTRATIONS: EFFECT OF SMOKING AND PECHLORATE

连续母乳碘浓度：吸烟和多氯酸盐的影响

• 批准号: 7606273
• 负责人: Elizabeth N. Pearce
• 金额: $ 1.01万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-01-03 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7606273
• 关键词: Breast Feeding; Chemicals; Computer Retrieval of Information on Scientific Projects Database; Cotinine; Dietary Iodine; Funding; Future; Grant; Human; Human Milk; Infant; Institution; Intake; Iodine; Measures; Multivitamin; Nicotine; Perchlorates; Research; Research Personnel; Resources; Sampling; Smoking; Source; Thyroid Hormones; Time; United States National Institutes of Health; Urine; critical developmental period; design; feeding; healthy volunteer; neurodevelopment; nutrition

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Thyroid hormone, whose synthesis is dependent on adequate iodine, is essential during the critical period of neurodevelopment. Breastfed infants are completely reliant on maternal iodine for adequate iodine nutrition. We plan to determine whether iodine concentration in human breast milk varies within a feed. We plan to use our findings to design future studies assessing breast milk iodine adequacy in the US. In our study, we will measure iodine concentrations in serial breast milk samples obtained from 30 healthy volunteers during a single breastfeed. Breast milk and urine concentrations of the chemical perchlorate and the nicotine metabolite cotinine will also be measured, given their possible associations with breast milk iodine content. Additionally, the timing of breast milk samples in relation to maternal dietary iodine intake and iodine-containing multivitamin use will be recorded and analyzed.

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