SEQUENTIAL BREAST MILK IODINE CONCENTRATIONS: EFFECT OF SMOKING AND PECHLORATE

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 甲状腺激素的合成依赖于充足的碘，在神经发育的关键时期是必不可少的。母乳喂养的婴儿完全依赖于母体碘来获得足够的碘营养。我们计划确定人类母乳中的碘浓度是否在饲料中变化。我们计划利用我们的研究结果来设计未来的研究，评估美国母乳碘的充足性。在我们的研究中，我们将测量30名健康志愿者在单次母乳喂养期间获得的系列母乳样本中的碘浓度。母乳和尿液中化学物质高氯酸盐和尼古丁代谢产物可替宁的浓度也将被测量，因为它们可能与母乳中的碘含量有关。此外，将记录并分析母乳样本采集时间与母体膳食碘摄入量和含碘复合维生素使用的关系。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Thyroid hormone, whose synthesis is dependent on adequate iodine, is essential during the critical period of neurodevelopment. Breastfed infants are completely reliant on maternal iodine for adequate iodine nutrition. We plan to determine whether iodine concentration in human breast milk varies within a feed. We plan to use our findings to design future studies assessing breast milk iodine adequacy in the US. In our study, we will measure iodine concentrations in serial breast milk samples obtained from 30 healthy volunteers during a single breastfeed. Breast milk and urine concentrations of the chemical perchlorate and the nicotine metabolite cotinine will also be measured, given their possible associations with breast milk iodine content. Additionally, the timing of breast milk samples in relation to maternal dietary iodine intake and iodine-containing multivitamin use will be recorded and analyzed.