VENTRAL STRIATAL DOPAMINE RESPONSE TO ETHANOL AND ITS CUES IN AT-RISK DRINKERS

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 动物模型表明，多巴胺（DA）区域，如腹侧被盖区（VTA）和丘脑核（NAc）是大脑奖励回路的关键部分，并与酗酒的遗传学有关。 我们建议使用正电子发射断层扫描（PET）来研究[11 C][雷氯必利（RAC，D2/D3配体）的结合电位变化（BP）作为酒精中毒风险受试者-具有酒精中毒家族史（FHA）的高酒精饮酒者（HED）的乙醇预期和消耗的函数。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Animal models show that dopamine (DA) regions such as the ventral tegmental area (VTA) and nucleus accumbens (NAc) are critical parts of the brain's reward circuit, and are implicated in the genetics of alcoholism. We propose using positron emission tomography (PET) to study binding potential changes (BP) in [11C[ Raclopride (RAC, D2/D3 ligand) as a function of ethanol anticipation and consumption in subjects at risk for alcoholism -- High-ethanol drinkers (HED) with a family history of alcoholism (FHA).