INSULIN SENSITIVITY AND VASCULAR FUNCTION IN NON-ALCOHOLIC STEATOHEPATITIS-NASH

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 在没有病毒性肝炎和酒精相关疾病的受试者中，NASH是最常见的肝硬变原因。NASH常见于肥胖者，提示存在胰岛素抵抗的潜在作用。NASH的原因尚不清楚，但可能是由于血管和/或代谢变化或两者的组合。为了更好地了解血管功能和葡萄糖代谢之间的关系，我们计划评估血管内皮依赖性和非依赖性血管扩张剂对NASH患者的腿部血流反应和胰岛素敏感性。腿部血流量将通过热稀释技术进行评估。胰岛素敏感性将使用正常血糖高胰岛素钳夹来测量。我们将把我们的研究结果与我们自己的标准数据(与肥胖匹配的女性研究)进行比较。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. NASH is the most common cause of liver cirrhosis in subjects without viral hepatitis and alcohol related disease. NASH is frequently observed in obese subjects suggesting a potential role of insulin resistance. The cause of NASH is not known but may be due to vascular and/or metabolic changes or a combination of each. To gain better understanding of the relation between vascular function and glucose metabolism we plan to assess leg blood flow responses to endothelium-dependent and -independent vasodilators and insulin sensitivity in subjects with biopsy proven NASH. Leg blood flow will be evaluated by thermodilution technique. Insulin sensitivity will be measured using the euglycemic hyperinsulinemic clamp. We will compare results of our study with out own normative data (studies with females matched for obesity).