FIFTY-YEAR MEDALIST

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这是一项对被授予乔斯林五十年勋章的个人的横断面观察研究。Joslin的奖章计划表彰患有胰岛素依赖型糖尿病25年、50年和75年的个人，并颁发特别奖项，以纪念他们对终生糖尿病管理的奉献。 根据之前的兴趣和预计的奖牌获得者数量，预计将有大约400名受试者参加这项研究。这项研究有三个具体目的，第一个目的是记录与糖尿病相关的微血管和大血管并发症(神经病变、肾病、视网膜病变和心血管疾病)的临床证据。第二个具体目标是检查生化因素，这可能有助于理解为什么一些奖牌获得者能够在没有并发症的情况下存活下来。第三个具体目标是在第二个目标之后，检查与血管损伤的生理途径相关的基因多态。数据采集期预计为两年。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a cross-sectional observational study of individuals who have been awarded the Joslin fifty year medal. Joslin's Medal Program recognizes individuals who have lived with insulin-dependent diabetes for 25, 50 and 75 years with special awards to commemorate their dedication to lifelong diabetes management. Approximately 400 subjects are expected to enroll in the study based on previous interest and the number of expected Medalists. There are three specific aims of the study, the first of which is to document the clinical evidence of micro and macrovascular complications associated with diabetes (neuropathy, nephropathy, retinopathy, and cardiovascular disease). The second specific aim is an examination of biochemical factors which may help in understanding why some Medalists have been able to survive without complications. The third specific aim follows on the second, to examine genetic polymorphisms which have been associated with the physiologic pathways of vascular damage. The period of data collection is expected to be two years.