SEX DIFFERENCES IN NEUROENDOCRINE AND IMMUNOLOGIC RESPONSES IN IRRITABLE BOWE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 具体目标： 通过对男性和女性健康对照和肠易激综合征(IBS)患者的研究，本研究的目的是：1)确定女性和男性在下丘脑-垂体-肾上腺(HPA)轴反应性和交感神经系统(SNS)激活方面的差异，2)将这些发现与结肠组织炎症标志物和细胞因子谱相关联，3)确定结肠组织变化是否与内脏疼痛敏感性的性别差异有关。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. SPECIFIC AIMS: By studying male and female healthy controls and irritable bowel syndrome (IBS) patients, the purposes of this study are: 1) to determine if females and males differ in hypothalamic-pituitary-adrenal (HPA) axis responsiveness and sympathetic nervous system (SNS) activation, 2) to correlate these findings with markers of colonic tissue inflammation and cytokine profiles, and 3) to determine if colonic tissue alterations are related to sex-related differences in visceral pain sensitivity.