THE LONGITUDINAL STUDY OF THE OCULAR COMPLICATIONS OF AIDS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 艾滋病眼部并发症纵向研究(LSOCA)是一项前瞻性的观察性研究，旨在提供面对不断变化的抗HIV和抗CMV疗法时艾滋病眼部并发症的发生率和病程的信息。目标是： -监测巨细胞病毒性视网膜炎和艾滋病其他眼部并发症发病率的长期趋势 -确定HAART引起的免疫状态变化对巨细胞病毒视网膜炎和艾滋病的其他眼部并发症风险的影响。 -确定巨细胞病毒视网膜炎和艾滋病其他眼部并发症高危人群的特征(临床、病毒学、血液学和生化)。 -评估巨细胞病毒视网膜炎和其他眼部并发症的治疗对视觉功能、生活质量和生存的影响。 这项研究是由NIH/NEI资助的名为艾滋病眼部并发症研究(SOCA)的多中心试验小组的一部分。 2.调查员背景： 库普曼博士是加州大学欧文分校眼科副教授。库普曼博士撰写并发表了大量关于艾滋病患者巨细胞病毒视网膜炎和其他感染的管理方面的文章和演讲。近期出版的出版物包括：

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Longitudinal Study of the Ocular Complications of AIDS (LSOCA) is a prospective, observational study designed to provide information on the incidence and course of ocular complications of AIDS in the face of changing anti-HIV and anti-CMV therapies. The objectives are: - To monitor secular trends in the incidence of CMV retinitis and other ocular complications of AIDS - To determine the effect of HAART-induced changes in immune status on the risk of CMV retinitis and other ocular complications of AIDS. - To determine the characteristics (clinical, virologic, hematologic, and biochemical) of populations at high risk for CMV retinitis and other ocular complications of AIDS. - To evaluate the effects of treatments for CMV retinitis and other ocular complications on visual function, quality of life, and survival. This study is being performed as a part of a multicenter trial group funded by the NIH/NEI called the Studies of the Ocular Complications of AIDS (SOCA). 2. BACKGROUND OF THE INVESTIGATOR: Dr. Kuppermann is an Associate Professor in the Department of Ophthalmology at the University of California, Irvine. Dr. Kuppermann has written and lectured extensively on the management of CMV retinitis and other infections in AIDS patients. Recent publications include: